Comparison Of Efficacy Of Dexmedetomidine And Labetalol For Attenuation Of Haemodynamic Stress Response To Laryngoscopy And Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine
研究概览
简要总结
Laryngoscopy and endotracheal intubation has its own set of complications like increase in heart rate , blood pressure, intraocular, and intracranial pressure. The haemodynamic changes stemming from airway instrumentation are due to sympathoadrenal discharge caused by epipharyngeal and parapharyngeal stimulations.
Labetalol is an unique oral and parenteral antihyper- tensive drug that is alpha-1 and nonselective beta-1 and beta-2 adrenergic antagonist.Its overall effect on cardiac output remains unchanged. It reaches its peak effect at 5-15 minutes after intravenous (IV) injection and has 5.9 minutes of redistribution half-life. It decreases BP by lowering systemic vascular resistance (α1-blockade), whereas reflex tachycardia caused by vasodilatation is decreased by β-blockade with unchanging cardiac output.
Dexmedetomidine is a comparatively newer drug and an imidazole derivative and selective alpha 2 adrenergic receptor agonist. Alpha 2 agonists produce hyperpolarization of noradrenergic neurons and suppression of neuronal firing in the locus ceruleus which leads to decreased systemic noradrenaline release resulting in attenuation of sympathoadrenal responses and hemodynamic stability during laryngoscopy and tracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of age between 18-60 years of both gender ASA 1 and 2 Undergoing elective surgical procedure requiring general anaesthesia and endotracheal intubation Written and informed consent.
排除标准
- •Patient refusal to participate in the study Allergy to study medications Patients with H/o cardiac, respiratory, renal or hepatic dysfunction or failure.
- •Pregnant females Patients on Antihypertensive drugs Patients with difficult intubation and those patients in whom intubation was attempted for more than 30 seconds or 2 attempts.
结局指标
主要结局
Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine
时间窗: Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine by comparing Haemodynamic parameters (HR,SBP,DBP,SPO2)at baseline,after infusion of study drug,after induction of anaesthesia,immediately after intubation,1,3,5,10 minutes after intubation
次要结局
- Postoperative sedation by Ramsay scale and adverse effects if occurs(Sedation by Ramsay scale at immediately after intubation and 15min,30 min,1hr,2hr,4hr,6hr)