two different drugs have given to attenuate the heamodynamic stress response to laryngoscopy and intubation

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/01/048938
• Lead Sponsor: Health and family welfare department

Brief Summary

Laryngoscopy and endotracheal intubation  has its own set of complications like  increase in heart rate , blood pressure, intraocular, and intracranial pressure. The haemodynamic changes stemming from airway instrumentation are due to sympathoadrenal discharge caused by epipharyngeal and parapharyngeal stimulations.

Labetalol is an unique oral and parenteral antihyper- tensive drug that is alpha-1 and nonselective beta-1 and beta-2 adrenergic antagonist.Its overall effect on cardiac output remains unchanged. It reaches its peak effect at 5-15 minutes after intravenous (IV) injection and has 5.9 minutes of redistribution half-life. It decreases BP by lowering systemic vascular resistance (α1-blockade), whereas reflex tachycardia caused by vasodilatation is decreased by β-blockade with unchanging cardiac output.



Dexmedetomidine is a comparatively newer drug and an imidazole derivative and selective alpha 2 adrenergic receptor agonist. Alpha 2 agonists produce hyperpolarization of noradrenergic neurons and suppression of neuronal firing in the locus ceruleus which leads to decreased systemic noradrenaline release resulting in attenuation of sympathoadrenal responses and hemodynamic stability during laryngoscopy and tracheal intubation.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-11-01
• Study Start: 2023-12-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Patients of age between 18-60 years of both gender ASA 1 and 2 Undergoing elective surgical procedure requiring general anaesthesia and endotracheal intubation Written and informed consent.

Exclusion Criteria

• Patient refusal to participate in the study Allergy to study medications Patients with H/o cardiac, respiratory, renal or hepatic dysfunction or failure.
• Pregnant females Patients on Antihypertensive drugs Patients with difficult intubation and those patients in whom intubation was attempted for more than 30 seconds or 2 attempts.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine	Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine by comparing Haemodynamic parameters (HR,SBP,DBP,SPO2)at baseline,after infusion of study drug,after induction of anaesthesia,immediately after intubation,1,3,5,10 minutes after intubation

Secondary Outcome Measures

Name	Time	Method
Postoperative sedation by Ramsay scale and adverse effects if occurs	Sedation by Ramsay scale at immediately after intubation and 15min,30 min,1hr,2hr,4hr,6hr

Trial Locations

Locations (1)

Civil hospital Ahmedabad; 🇮🇳 Ahmadabad, GUJARAT, India

Civil hospital Ahmedabad

🇮🇳Ahmadabad, GUJARAT, India

Solanki Yogesh Naranbhai

Principal investigator

8200877199

yogeshsolanki95ys@gmail.com