Value of Pulse Pressure Variations and Corrected Flow Time in Esophageal Doppler as a Predictor of Fluid Responsiveness in Prone Position During Spinal Surgery

Not Applicable

Completed

• Conditions: Elective Posterior Lumbar Spinal Fusion
• Interventions: Device: 1.Esophageal doppler monitor; Device: 2. philips Intelivue MP70 monitors

• Registration Number: NCT01646359
• Lead Sponsor: Yonsei University

Brief Summary

In patients under mechanical ventilation, Usefulness of dynamic indices based on the heart-lung interactions for guiding volume resuscitation has been well validated. Recently, validity of pulse pressure variation (PPV) has been also reported to predict fluid responsiveness. Oesophageal Doppler (OED) allows continuous monitoring of several important hemodynamic variables. Of the OED variables, corrected flow time (FTc) has been evaluated and used as a preload index, and has been reported to predict fluid responsiveness. Prone position caused physiologic and hemodynamic changes and influenced the predictability and cut-off values of SVV and PPV for fluid responsiveness. In this prospective controlled study, the investigators evaluated the validity of PPV and FTc as predictors for fluid responsiveness in supine and prone position in patients undergoing posterior lumbar spinal fusion

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2012-07
• Study First Submitted: 2012-07-15
• Study First Submitted QC: 2012-07-19
• Last Update Submitted: 2012-07-19
• Study First Posted: 2012-07-20
• Last Update Posted: 2012-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• patients undergoing elective spine surgery
• age : > 20 and < 70, 3. Patients expecting intraoperative blood loss more than 10% of estimated blood volume

Exclusion Criteria

• arrhythmias
• BMI > 30 kg/m2
• valvular heart disease
• left ventricular ejection fraction < 50%
• history of lung disease
• pregnancy
• foreigner
• contraindications to esophageal doppler monitoring probe insertion (i.e. oesophageal stent, carcinoma of the oesophagus or pharynx, previous oesophageal surgery, oesophageal stricture, oesophageal varices, pharyngeal pouch, intra-aortic balloon pump, coarctation of the aorta, and severe coagulopathy)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
corrected flow time	1.Esophageal doppler monitor	-
corrected flow time	2. philips Intelivue MP70 monitors	-

Primary Outcome Measures

Name	Time	Method
PPV(Pulse pressure variation)	15 minutes after induction of anaesthesia at the supine position
FTc(corrected flow time)	15 minutes after induction of anaesthesia at the supine position

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia; 🇰🇷 Seoul, Korea, Republic of