Value of Pulse Pressure Variations and Corrected Flow Time in Esophageal Doppler as a Predictor of Fluid Responsiveness in Prone Position During Spinal Surgery

Yonsei University1 site in 1 country45 target enrollmentMarch 2011

ConditionsElective Posterior Lumbar Spinal Fusion

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Elective Posterior Lumbar Spinal Fusion
Sponsor: Yonsei University
Enrollment: 45
Locations: 1
Primary Endpoint: PPV(Pulse pressure variation)
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In patients under mechanical ventilation, Usefulness of dynamic indices based on the heart-lung interactions for guiding volume resuscitation has been well validated. Recently, validity of pulse pressure variation (PPV) has been also reported to predict fluid responsiveness. Oesophageal Doppler (OED) allows continuous monitoring of several important hemodynamic variables. Of the OED variables, corrected flow time (FTc) has been evaluated and used as a preload index, and has been reported to predict fluid responsiveness. Prone position caused physiologic and hemodynamic changes and influenced the predictability and cut-off values of SVV and PPV for fluid responsiveness. In this prospective controlled study, the investigators evaluated the validity of PPV and FTc as predictors for fluid responsiveness in supine and prone position in patients undergoing posterior lumbar spinal fusion

Registry

clinicaltrials.gov

Start Date

March 2011

End Date

February 2012

Last Updated

13 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Yonsei University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•patients undergoing elective spine surgery
•age : \> 20 and \< 70,
•Patients expecting intraoperative blood loss more than 10% of estimated blood volume

Exclusion Criteria

•arrhythmias
•BMI \> 30 kg/m2
•valvular heart disease
•left ventricular ejection fraction \< 50%
•history of lung disease
•pregnancy
•foreigner
•contraindications to esophageal doppler monitoring probe insertion (i.e. oesophageal stent, carcinoma of the oesophagus or pharynx, previous oesophageal surgery, oesophageal stricture, oesophageal varices, pharyngeal pouch, intra-aortic balloon pump, coarctation of the aorta, and severe coagulopathy)