The Effects of Altering Physical Activity on Cardiometabolic Health

Not Applicable

Completed

• Conditions: Insulin Resistance
• Interventions: Behavioral: Exercise

• Registration Number: NCT01879059
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining \>10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

Detailed Description

Herein, we tested the hypothesis that an acute reduction in daily activity (from \>10,000 to \<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Study Timeline

• Study First Submitted: 2012-01-24
• Study Start: 2012-03
• Study First Submitted QC: 2013-06-14
• Study First Posted: 2013-06-17
• Primary Completion: 2014-10
• Study Completion: 2014-10
• Results First Submitted: 2014-10-14
• Status Verified: 2016-01
• Results First Submitted QC: 2016-01-04
• Last Update Submitted: 2016-01-04
• Results First Posted: 2016-02-08
• Last Update Posted: 2016-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• BMI: less than 30 kg/m2
• Physically active: exercise greater than 60mins per week

Exclusion Criteria

• smoking
• type 2 diabetes
• Underlying conditions that limit ability to exercise safely
• Recent weight gain or loss(> 5% of body weight in 3 months)
• Recent (< 3 mo) changes in medication use or dose
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	5 days of inactivity followed by a 1 day return to physical activity

Primary Outcome Measures

Name	Time	Method
Effects of Physical Inactivity on Post Prandial Blood Flow	10 days	There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity.

Trial Locations

Locations (1)

University of Missouri; 🇺🇸 Columbia, Missouri, United States