Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction
- Registration Number
- NCT00553995
- Lead Sponsor
- Boston University
- Brief Summary
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses. Subjects will be randomized to treatment with salsalate or placebo for four days prior to initiation of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment with salsalate will be associated with protection again the development of glucose intolerance and vascular dysfunction in this setting.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Healthy volunteers
Exclusion Criteria
- Pregnancy
- History of Coronary Artery Disease
- Diabetes Mellitus
- Hypertension
- Cigarette smoking
- History or family history of deep vein thrombosis or pulmonary embolism
- Abnormal renal function
- Liver function tests greater than two times the upper limit of normal
- Anemia
- Use of viagra or other PDE5 inhibitor
- Hypercholesterolemia
- Aspirin allergy/sensitivity
- Asthma with nasal polyps
- Peptic ulcer disease/Gastrointestinal bleeding
- Any ongoing drug treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo Salsalate salsalate Salsalate
- Primary Outcome Measures
Name Time Method Reactive hyperemia in the femoral artery 5 days
- Secondary Outcome Measures
Name Time Method Reactive hyperemia in the brachial artery 5 days Oral glucose tolerance test 5 days
Trial Locations
- Locations (1)
Boston University School of Medicine
🇺🇸Boston, Massachusetts, United States