The effect of dexmedetomidine infusion on post-operative cognitive function and oxidative stress in patients undergo cardiopulmonary bypass machine facilitated elective cardiac surgery.

Not Applicable

Not yet recruiting

• Conditions: Post- operative cognitive dysfunctionMajor Neurological complicationICU stayHospital stayIntubated time; Dexmedetomidine; Cardiac surgery; operative cognitive dysfunction; Oxidative stress

• Registration Number: TCTR20141110003
• Lead Sponsor: TRF

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-11-10
• Study Completion: 2015-01-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

The patient, whose age between 18 and 65 years, scheduled for cardiopulmonary bypass facilitated elective cardiac surgery

Exclusion Criteria

allergic to any drug in research protocol
left ventricular ejection fraction less than 30%
pre-operative severe hypotension (mean arterial pressure less than 60 mmHg)
pre-operative severe bradycardia (heart rate of less than 45 beat per minute)
co-existing psychological disorder
unable to take cognitive function test.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Cognitive Function 24 hour and 1 week post-operatively cognitive function test,Oxidative Stress and Inflammatory response preoperative, post-cardiopulmonary bypass machine termination, ICU admission, 24 hours Blood for hs-CRP, TNF-α, IL-6 and IL-10

Secondary Outcome Measures

Name	Time	Method
Post-operative Complication preoperative until discharged home data extraction from medical record