Effect of noninvasive ventilation on the synchrony of the upper airways and inspiration.

Recruiting

• Conditions: Chronic Obstructive Pulmonary Disease (COPD); lung emphysema; 10046304

• Registration Number: NL-OMON36867
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

1) Age >18
2) Informed consent
3) COPD
4) Hypercapnic respiratory acidosis
5) Clinical need of NIV ventilation on the intensive care
6) NAVA catheter in situ

Exclusion Criteria

1) Pre-existent muscle disease (congenital or acquired) or diseases / disorders known to be associated with myopathy including auto-immune diseases.
2) Upper airway/esophageal/mouth or face pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
3) Diabetes
4) Recent (< 1 month) nasal bleeding
5) Allergic to xylocaïne

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the extent of glottis closure during diaphragm<br /><br>activation and the time delay in glottis opening with respect to diaphragm<br /><br>activity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives are to investigate whether the level of support and the<br /><br>triggering mode of noninvasive ventilation induces or influences glottis<br /><br>behavior.</p><br>