The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Phase 4

Completed

• Conditions: Prostate Cancer
• Interventions: Drug: Desflurane; Drug: propofol

• Registration Number: NCT02149628
• Lead Sponsor: Yonsei University

Brief Summary

Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.

Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.

To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.

Secondarily, kidney protection effect of propofol over desflurane will be compared.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2014-05-19
• Study First Submitted QC: 2014-05-26
• Study First Posted: 2014-05-29
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Status Verified: 2015-07
• Last Update Submitted: 2015-07-27
• Last Update Posted: 2015-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia

Exclusion Criteria

• chronic renal failure ( estimated glomerular filtration rate <60 mL/min/1.73m2)
• allergy to propofol, nuts
• on diuretics, vitamin C or vitamin E within 5 days before surgery
• Body mass index > 30 kg/m2
• older than 70 years
• who cannot read the patient consent form

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
desflurane	Desflurane	use desflurane as a primary anesthetics during anesthesia guided by bispectral index (BIS)
propofol	propofol	propofol infusion with target-controlled infusion(TCI) device guided by BIS

Primary Outcome Measures

Name	Time	Method
changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation	100 min after pneumoperitoneum, 10 min after decompression

Secondary Outcome Measures

Name	Time	Method
kidney function after anesthesia	1 day after operation	measure creatinine

Trial Locations

Locations (1)

Yonsei University, Gangnam Severance Hospital; 🇰🇷 Seoul, Korea, Republic of