Heliox delivered by high flow nasal cannula in infants with acute bronchiolitis
- Conditions
- Respiratory syncytial virus acute bronchiolitisRespiratoryRespiratory syncytial virus acute bronchiolitis
- Registration Number
- ISRCTN99072045
- Lead Sponsor
- Mansoura University Children Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
1. Infants aged from 1 month to 2 years old
2. Patients who are admitted to the pediatric high dependency unit, with RSV acute bronchiolitis diagnosed clinically confirmed by laboratory testing
3. Display the diagnostic criteria of bronchiolitis including cough, tachypnea, chest retraction, prolonged expiratory time, sibilant rhonchi, and hyperinflation of the lungs
3. Cannot maintain oxygen saturation = 93% in room air and require supplemental oxygen on admission to hospital
1. No informed consent obtained
2. Require mechanical ventilation
3. Congenital heart defect that is haemodynamically significant (significant left-to-right shunting with or without pulmonary hypertension or right-to-left shunting)
4. Underlying chronic lung disease including bronchopulmonary dysplasia and previously diagnosed hyper-reactive airway diseases
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Partial arterial pressure and partial arterial oxygen are assessed using arterial blood samples at baseline, 2 hours and 24 hours<br>1.1. Oxygen saturation is assessed using pulse Masimo SET pulse oximeter continuously throughout the intervention<br>2. Respiratory distress is measured by the Modified Wood’s Clinical Asthma Score at 2 hours and 24 hours
- Secondary Outcome Measures
Name Time Method ength of hospital stay is measured by reviewing patient notes at the end of hospital stay.