Cheese Intake and Hypercholesterolemia
- Conditions
- Hypercholesterolemia
- Registration Number
- NCT01570270
- Lead Sponsor
- Azienda Ospedaliera Brotzu
- Brief Summary
In this study the investigators aimed at verifying whether consumption of a sheep cheese, naturally enriched in alpha-lipoic acid (ALA), conjugated linoleic acid (CLA) and vaccenic acid (VA), would modify the plasma lipid and endocannabinoid profiles in mild hypercholesterolemic subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
- 42 adult volunteers (19 male and 23 female) with diagnosed mild hypercholesterolemia (total cholesterol 220-290 mg/dL),
- 30-60 years of age
-
Pregnant (or those planning to become pregnant during the study period) and lactating women were excluded;
-
also individuals with a self-reported history of diabetes, inflammatory bowel disease, pancreatitis, gallbladder or biliary disease in the past 12 months, and lactose intolerance before the screening visit.
-
In addition, those with a history of cancer (except non-melanoma skin cancer) in the 2 years before screening, or of any major trauma or surgical event within 3 months before screening, were not enrolled.
-
Volunteers with the following characteristics were also excluded:
- total cholesterol ≥ 300 mg/dL,
- serum triglycerides ≥ 250 mg/dL or ≤ 200 mg/dL,
- HDL ≥ 70mg/dL,
- BMI ≥ 30, or
- uncontrolled hypertension (systolic blood pressure ≥ 160 mm Hg or
- diastolic blood pressure ≥ 100 mm Hg) at screening.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method modification of LDL-cholesterol levels baseline and 3 weeks
- Secondary Outcome Measures
Name Time Method