Mechanism of action of 0.1% Tacrolimus ointment in combination with phototherapy in treatment of vitiligo
Not Applicable
- Conditions
- vitiligo.Vitiligo
- Registration Number
- IRCT20181117041686N1
- Lead Sponsor
- Skin Research Center of Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
patients with symmetrical, unstable and non-segmental vitiligo
Exclusion Criteria
receiving any topical or systemic treatments during the last 3 months
pregnancy, lactation
history of any hypersensitivity to tacrolimus
history of premalignant or malignant skin lesions
photosensitivity, photo-mediated disorders, taking photo-sensitizing drugs
concomitant radiotherapy, chemotherapy, or immunosuppressive therapy
segmental or mucosal vitiligo
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Melanocyte stem cells location. Timepoint: before intervention and 2 months after intervention. Method of measurement: staining of the skin samples using monoclonal antibodies for the melanocytes and assessing the slides under a microscope.
- Secondary Outcome Measures
Name Time Method The percentage of skin repigmentation. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Using a quartile grading scale (grade 0, no repigmentation; grade 1, 1%-24%; grade 2, 25%-49%; grade 3, 50%-74%; grade 4, 75%-99%; grade 5, complete resolution).