Restrictive versus Liberal Thresholds for Red Blood Cell Transfusion in ExtraCorporeal Membrane Oxygenatio
- Conditions
- Anemia10038158
- Registration Number
- NL-OMON56298
- Lead Sponsor
- Amsterdam UMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 335
Inclusion Criteria
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Patient is aged 18 years or older;
- Is receiving ECMO;
- (Deferred) informed consent.
Exclusion Criteria
A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Not expected to survive for 24 hours when assessed;
- Inability to receive blood products;
- (Known) decline to blood transfusions;
- Aged younger than 18 years;
- Extracorporeal carbon dioxide removal (ECCO2R) using low blood flow devices
or pumpless devices
- Received ECMO over 48h before screening for eligibility.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome parameter is 90-day all-cause mortality.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes include: 1) proportion of patients on ECMO exposed to<br /><br>allogeneic RBC transfusion; 2) RBC volume infused per patient during ECMO; 3)<br /><br>reasons for RBC transfusion other than Hb triggers; 4) transfusion reactions;<br /><br>5) time on ECMO; 6) length of hospital- and ICU-stay; 7) in-ICU morbidity; 8)<br /><br>quality of life (QoL) at 12 months; 9) costs related to a) transfusion, b)<br /><br>hospital admission and c) transfusion-related sequelae.</p><br>