Preventing Cognitive Decline in HIV-infected Latinos Through a Culturally Tailored Health Promotion Intervention (HOLA)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Percentage of Participants Completing the Study
研究概览
简要总结
The purpose of this study is to look at the best ways to prevent cognitive decline (loss of memory and/or functioning) in midlife and older Latino adults living with HIV.
详细描述
The purpose of this study is to look at the best ways to prevent cognitive decline (loss of memory and/or functioning) in midlife and older Latino adults living with HIV. It assesses the feasibility of running a health promotion program, led by a community health worker (CHW) intended to help prevent cognitive decline (loss of memory and/or functioning) through a culturally tailored health promotion intervention . Eligible participants will be Latino/Hispanic individuals 50 years of age or older, living with HIV, who may be at risk of developing chronic diseases such as dementia and Alzherimer's.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •are Latino (self-identified);
- •are age 50+;
- •are HIV infected but are virologically suppressed (viral load <200 copies/mL);
- •volunteer informed consent
排除标准
- •have diagnosis of any neurodegenerative disorder or dementia (Parkinson's disease, Alzheimer's disease, vascular, frontotemporal dementia, etc.) or significant cognitive impairment as indicated by a Telephone Interview for Cognitive Status (TICS) score less than or equal to 30;
- •have other conditions that could impact cognitive functioning or testing (e.g., legally blind or deaf), currently undergoing radiation or chemotherapy, a history of brain trauma with a loss of consciousness greater than 30 minutes.
- •have contraindications to physical activity outlined in the American College of Sports Medicine standards or severe medical illness that precludes them from safely participating in a health promotion intervention.
- •are unable to complete 10-meter walk test.
- •have plans to move outside of the Miami metropolitan area within the next 6 months or are not living in stable housing (e.g. group home).
结局指标
主要结局
Percentage of Participants Completing the Study
时间窗: 16 weeks
Feasibility of HOLA will be reported as the percentage of participants completing the post intervention assessment.
次要结局
- Changes in Neurocognitive Impairment as Measured by the Trails Making Test(Baseline, 16 weeks)
- Changes in Neurocognitive Impairment as Measured by the WAIS-IV Digit Span(Baseline, 16 weeks)
- Changes in Physical Activity as Measured by the Global Physical Activity Questionnaire (GPAQ)(Baseline, 16 weeks)
- Changes in Depression as Measured by the PHQ-9(Baseline, 16 weeks)
- Changes in Anxiety as Measured by the GAD-7(Baseline, 16 weeks)
- Changes in Psychosocial Functioning as Measured by the MSPSS(Baseline, 16 weeks)
- Changes in Biomarkers of Cognition(Baseline, 16 weeks)
- Changes in Biomarkers of Cognition Levels(Baseline, 16 weeks)
- Changes in Adiponectin(Baseline, 16 weeks)
研究者
Daniel Enrique Jimenez
Associate Professor
University of Miami