Effect of protein intake on skeletal muscle health among healthy Indian adults

Recruiting

Conditions: Healthy controlsAge: 25-45 yearsBMI: 18.5- 24.9 kg/m2 Both males and femalesMuscle strength 1 SD from Indian data set

Brief Summary: Protein ingestion (source, dose, timing, and pattern) is a key stimulus for preserving skeletal muscle mass and strength. Inadequate protein intake causes an imbalance in protein metabolism in skeletal muscle health. This in turn could lead into loss in muscle mass and strength. Understanding the role of adequate protein intake and its impact on muscle health is important among Indian population, as majority of the population consume cereal based diet. With ageing changes in muscle health has been reported. The consequence of loss of muscle mass and strength with ageing will lead to reduced physical activity further causing chronic diseases. One of the ways it can be delayed is by providing adequate nutrition and exercise during middle age. So overall goal of the study is to increase our understanding of the role of protein supplementation and simple exercise like brisk walking among Indians on muscle health (muscle mass and strength).

Recruitment & Eligibility

Inclusion Criteria

Healthy controls BMI: 18.5- 24.9 kg/m2 Muscle strength < 1 SD from Indian data set.

Exclusion Criteria

H/O chronic diseases (Prediabetes, Type 2 DM, Hypertension, tuberculosis, cancer, chronic renal failure, ischemic heart disease, infections[tuberculosis, typhoid, dengue, etc.
in the last 3 months etc) 2.
H/O allergy to any form of protein intake (ex: soy) 3.
Lactose intolerance 4.
Alcohol intake greater than 2 STD per day 5.
Any form of anaemia 6.
Any form of peripheral neuropathy 7.
Muscular dystrophies 8.
Any form of surgeries on knee and wrist 10.
History of osteoarthritis 11.
Pregnancy 12.
Consumption of protein supplements/nutritional supplement or Excess intake of protein than recommended 13.
Those who exercise regularly (any form of resistance exercise/ heavy exercise, etc.).

Primary Outcome Measures

Name	Time	Method
1. To study the acute effect of (12g) protein consumption on the changes in amino acid pool (through amino-acidomics) and skeletal muscle health (strength, endurance and fatigability) among healthy Indian adults.	1.Acute study- Baseline, Day 7 \| 2. Chronic study- Baseline, end of 8th week
2. To study the combined effect of 8 week protein supplementation and aerobic exercise (150 min brisk walking) on the changes in skeletal muscle health and amino acid pool among healthy Indian adults.	1.Acute study- Baseline, Day 7 \| 2. Chronic study- Baseline, end of 8th week

Secondary Outcome Measures

Name	Time	Method
To study the combined effect of 8 week protein supplementation and aerobic exercise (150 min brisk walking) on the changes in skeletal muscle health and amino acid pool among healthy Indian adults.	Chronic study- Baseline, end of 8th week

Locations (1): St Johns Medical College
🇮🇳
Bangalore, KARNATAKA, India
St Johns Medical College
🇮🇳Bangalore, KARNATAKA, India
Dr Sucharita S
Principal investigator
080-49466301
sucharita@stjohns.in