Effect of deep magnetic stimulation on brain neural connection in schizophrenia

Not Applicable

Conditions: Health Condition 1: F20- Schizophrenia

Registration Number: CTRI/2023/03/050780

Lead Sponsor: IndiaAlliance,DBT wellcome

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1 Patients with diagnosis of schizophrenia as per DMS 5 and prominent negative symptoms with a score of 3 or more on each domain of affective flattening, alogia, avolition-apathy and anhedonia-asociality in Scale for Assessment of Negative Symptoms (SANS)

2 Stable dose of oral antipsychotics (defined as <25% change in dose) for the past 6 weeks and/or parenteral antipsychotics for the past 12 weeks

3 Age of 18 â?? 60 years

4 Both male and female gender

5 Written informed consent from the patient

Exclusion Criteria

1 Psychiatric emergency necessitating parenteral rescue medications or electroconvulsive therapy

2 Pregnancy or postpartum state

3 Substance use disorder in last 6 months

4 Co-morbid neurological or medical disease that can affect the brain structure or function

5 Any contraindication for Magnetic Resonance Imaging

6 Any contraindication for Transcranial Magnetic Stimulation

7 Clinically determined visual or hearing impairment

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To examine the effect of deep TMS using H7 coil on resting state functional connectivity of default mode network in schizophrenia patients with prominent negative symptomsTimepoint: Assesments at baseline, immediately post treatment

Secondary Outcome Measures

Name	Time	Method
To examine association between change in resting state functional connectivity of DMN with change in measures of social cognition, general cognition and insight into illness <br/ ><br>To examine the effect of treatment on total negative symptom score in the patients <br/ ><br>To do a mediation analysis to assess the effect of DMN resting state functional connectivity on negative symptoms through changes in social cognition, general cognition and insight into illness. <br/ ><br>Timepoint: Assessments at baseline, Immediately post treatment and 3 months after treatment