Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder
Completed
- Conditions
- Urge Urinary Incontinence
- Registration Number
- NCT01619995
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
The goal of this project is to evaluate the applicability of non-invasive optical imaging for the measurement of brain function during investigation of the lower urinary tract.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 43
Inclusion Criteria
- ambulatory women over age 60, who are incontinent at least five times weekly for 3 months despite correction of potentially reversible causes.
- urinary incontinence (urge or predominantly urge) by clinical criteria.
- able to accurately complete a voiding diary, to perform a 24-hour pad test under direction.
Exclusion Criteria
- significant mental impairment [mini mental status exam (MMSE) ≤ 20)
- urethral obstruction
- history of bladder cancer
- spinal cord lesions
- multiple sclerosis
- pelvic radiation
- interstitial cystitis
- artificial sphincter implant
- expected to have changes in medications/doses during the trial
- medically unstable
- Patients with factors that could cause transient UI [e.g., current urinary tract infection (UTI), acute confusion] will be treated in concert with the subject's primary care provider and considered for enrollment if their UI persists.
- conditions that require endocarditis prophylaxis (such as heart valve problems or bacterial endocarditis)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the brain-bladder control pathway in urge urinary incontinence patients?
How does non-invasive optical brain imaging compare to fMRI in urodynamic studies for bladder control?
Are there specific biomarkers that correlate with neural activity patterns during bladder function assessment?
What adverse events are associated with optical brain imaging during lower urinary tract investigations?
What combination therapies are being explored alongside brain imaging for urge urinary incontinence management?
Trial Locations
- Locations (1)
Geriatric Continence Research Unit, NE547 Montefiore UPMC
🇺🇸Pittsburgh, Pennsylvania, United States
Geriatric Continence Research Unit, NE547 Montefiore UPMC🇺🇸Pittsburgh, Pennsylvania, United States