The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Amphetamine Addiction
- Sponsor
- Shanghai Mental Health Center
- Enrollment
- 560
- Locations
- 1
- Primary Endpoint
- the prevalence of ATS abuse or dependence characteristics and pathogenesis
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this research is to inspire new medical ideas using brain image technology for the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition damage.
Detailed Description
The study will increase the sample size based on the preliminary work,also, establish drug dependence induced craving associated environmental experiments , by using the multi-lead biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T high-field magnetic resonance imaging system to record the physiology , electrophysiology and brain changes during craving, taking a subjective self-assessment , clinical observations and physiological responses combined system to evaluate the ATS addiction degree.
Investigators
Min ZHAO
Vice President
Shanghai Mental Health Center
Eligibility Criteria
Inclusion Criteria
- •No previous history of any mental disorder meet the DSM-IV diagnosis
- •aged 18-49 years old , men and women
- •junior high school or higher education
- •use of amphetamine-type substances time for more than one year
- •cumulative use of amphetamines, substances dose of 50 grams or more.
Exclusion Criteria
- •Current or past had suffered neurological diseases
- •exclusion of antisocial personality disorder and borderline personality disorder
- •addicts in addition to other substances in tobacco , coffee, social drinking outside
- •AIDS virus (HIV) detection positive patients .
Outcomes
Primary Outcomes
the prevalence of ATS abuse or dependence characteristics and pathogenesis
Time Frame: Baseline
Plasma and DNA samples were collected to carry out the biochemical genetics and immunology research of ATS abuse or dependence , and to explore the prevalence of ATS abuse or dependence characteristics and pathogenesis.
the physiological psychology and cognitive impairment characteristic of ATS addicts,trends and ATS conducted cases.
Time Frame: Baseline
Use repeatable battery for the assessment of neuropsychological status(RBANS),Cog-state cognitive function assessment test,event-related potentials(ERPs),functional magnetic resonance imaging(fMRI) in biology ( molecular genetics, blood biochemistry, electrophysiology , imaging ) , psychology, mental health and other aspects of the system to assess the physiological psychology and cognitive impairment characteristic of ATS addicts , trends and ATS conducted cases.