Exercise & Overweight Children's Cognition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 175
- 试验地点
- 2
- 主要终点
- Change in functional MRI
研究概览
简要总结
This research focuses on overweight, sedentary children whose health, cognition, and academic performance are therefore at risk, and who may be particularly responsive to exercise interventions.
This study will determine whether regular exercise per se (i.e. compared to attention control, or placebo, condition) benefits children's cognition and achievement, and will provide insight into neural mechanisms. A substudy will examine exercise-induced changes in brain structure.
Provision of comprehensive evidence for the benefits of exercise on children's health may reduce barriers to vigorous physical activity programs during a childhood obesity epidemic by persuading policymakers, schools and communities that time spent in physical activity enhances, rather than detracts from, learning.
详细描述
An ancillary study adding cardiometabolic outcome measures was added (R01HL087923-02S1, http://projectreporter.nih.gov/project_info_description.cfm?aid=7880457\&icde=20104167)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 8 Years 至 11 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •8-11 years of age
- •Overweight or obese (BMI-for-age >= 85th percentile)
- •Able to participate in exercise testing and intervention
排除标准
- •Medical condition or medications that would interfere with measurements
- •Participation in weight control or formal exercise program outside physical education that meets more than 1 day/week
- •T-score > 75 on the BRIEF Behavior Regulation scale to avoid program disruption
结局指标
主要结局
Change in functional MRI
时间窗: Baseline, 8 months
Change in blood-oxygenation level dependent (BOLD) signal reflecting brain activation during executive function tasks
Change in Planning Scale scores
时间窗: Baseline, 8 months, one-year follow-up
The Cognitive Assessment System provides an individually administered standardized psychological assessment of executive function
次要结局
- Change in aerobic fitness(Baseline, 8 months, one-year follow-up)
- Change in BMI(Baseline, 8 months, one-year follow-up)
- Change in adiposity(Baseline, 8 months, one-year follow-up)
- Change in teacher ratings of classroom behavior(Baseline, 8 months)
- Change in academic achievement(Baseline, 8 months, one-year follow-up)
- Change in performance on executive function tasks(Baseline, 8 months)
- Change in Tower of London scores(Baseline, 8 months, one-year follow-up)
研究者
Catherine Davis
Professor of Pediatrics, Physiology & Graduate Studies
Augusta University