Chlamydia and Mycoplasma in Coronary Artery Disease

Completed

• Conditions: Atherosclerosis; Chlamydia Infections; Coronary Artery Disease; Mycoplasma Infections
• Interventions: Other: blood sample analysis - mycoplasma and chlamydia antibodies

• Registration Number: NCT00561028
• Lead Sponsor: Hospital de Base

Brief Summary

To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.

Detailed Description

One hundred and twenty-six patients were divided into 4 groups: Acute Coronary Syndrome with ST-elevation, Non-ST-elevation, stable coronary artery disease, and individuals without coronary disease. Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured at baseline and after 6 months.

Study Timeline

• Study Start: 2002-03
• Study Completion: 2004-11
• Status Verified: 2007-11
• Study First Submitted: 2007-11-19
• Study First Submitted QC: 2007-11-19
• Last Update Submitted: 2007-11-19
• Study First Posted: 2007-11-20
• Last Update Posted: 2007-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 138

Inclusion Criteria

• Age >18 yrs
• Males and females
• Agreed to sign the informed consent

Exclusion Criteria

• Refusal to sign the informed consent
• Follow-up not possible
• For the "acute" groups, time between the pain beginning and randomization >24 hours
• Active infections
• Use of antimicrobial agents within the last 30 days
• End-stage diseases with life expectancy <6 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	blood sample analysis - mycoplasma and chlamydia antibodies	ST-elevation acute myocardial infarction.
3	blood sample analysis - mycoplasma and chlamydia antibodies	known coronary artery disease, either asymptomatic or with stable angina.
4	blood sample analysis - mycoplasma and chlamydia antibodies	blood donors without known coronary artery disease.
2	blood sample analysis - mycoplasma and chlamydia antibodies	high-risk unstable angina or non-ST-elevation myocardial infarction.

Primary Outcome Measures

Name	Time	Method
Test the hypothesis that patients with acute coronary syndromes have higher levels of Chlamydia pneumonia and Mycoplasma pneumonia antibodies in comparison with patients with stable coronary artery disease or controls.	6 months