Comparing surgical treatment outcomes in patients with different lung diseases and breathing tube repair types

Not Applicable

Completed

• Conditions: Pneumonectomy for pulmonary cancer, tuberculosis or nonspecific chronic inflammatory lung diseases.; Surgery

• Registration Number: ISRCTN17157026
• Lead Sponsor: Sechenov University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-09-01
• Study Start: 2021-09-20
• Last Update Posted: 4 October 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 2001

Inclusion Criteria

All patients who have had a pneumonectomy from 1959 to 2021 at the following institutions:
1. State Budgetary Healthcare Institution Chelyabinsk Regional Clinical Anti-Tuberculosis Dispensary 38, Vorovskogo str., Chelyabinsk, Russian Federation, 454092. From 1959 to 2004
2. Central TB Research Institute, 2, Yauzskaya alley, Moscow, Russian Federation, 107564 From 2004-2011
3. Sechenov University Phthisiopulmonology Clinical Hospital, 4, Dostoevskogo str., Moscow, Russian Federation, 127473. From 2011 to 2017
4. Ingush Republican TB Dispensary, 1, Bolnichnaya str., Plievo Village, Nazranovsky District, Republic of Ingushetia, Russian Federation, 386124. From 2018 to 2021
5. Regional Clinical Tuberculosis Dispensary, 22, Volskaya str., Saratov, Russian Federation, 410056. From 2018 to 2021
6. JSC «MEDICINE» (CLINIC OF ACADEMICIAN ROYTBERG), 10, 2nd Tverskoy-Yamskoy Pereulok, Moscow, Russian Federation, 125047. From 2018 to 2021

Exclusion Criteria

1. Patients admitted before 14/11/1959 and after 01/09/2021
2. Patients who passed lung resections in volume less than pneumonectomy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Measured retrospectively using patient records:<br> 1. Bronchopleural fistula development<br> 2. 30-day postoperative mortality rate<br> 3. Postoperative long term bronchopleural complications<br> 4. Postoperative mortality due to bronchopleural complications<br>

Secondary Outcome Measures

Name	Time	Method
<br> Measured retrospectively using patient records:<br> 1. Surgery efficacy in patients with tuberculosis measured using<br> 1.1. Sputum culture conversion rate after surgery and one, three and five years after surgery<br> 1.2. Presence of cavities in pulmonary tissue (CV+/CV-) determined with CT scan/digital X-ray on discharge from the hospital, one, three and five years post-surgery.<br> 2. Surgery efficacy in oncology patients measured using<br> 2.1. Clear resections edges<br> 2.2. R0 resection<br> 2.3. 5-year survival rate<br> 3. Surgery efficacy in patients with nonspecific chronical inflammatory lung diseases measured using absence of inflammatory process according to microbiological, roentgenological and clinical analysis after surgery and one, three and five years after surgery.<br> 4. Five-year survival rate<br>