A trial to compare two treatment options for Landry Guillain Barre Syndrome (A form of paralysis) in childre
Not Applicable
- Conditions
- Health Condition 1: G610- Guillain-Barre syndrome
- Registration Number
- CTRI/2020/12/029502
- Lead Sponsor
- Manjinder Singh Randhawa
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Admitted with a diagnosis of Landry Guillain Barre Syndrome
2. Requiring Mechanical Ventilation
3. Presentation <14 days from onset of symptoms
Exclusion Criteria
1. Treatment with IvIg or PE prior to admission
2. History of prior episode of LGBS
3. Patients with known malignancy, AIDS, IgA deficiency
4. Patients with a known chronic neurological/neuromuscular disorder
5. Patients with a known Renal Failure/Cardiac dysfunction
6. Patients with a history of a transfusion reaction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the mean duration of mechanical ventilation among ventilated children less than12 years of age with Landry Guillain Barre Syndrome who undergo Therapeutic Plasma Exchange (5 Cycles) with those who receive Intravenous Immunoglobulin (@ 2g/kg)Timepoint: To compare the mean duration of mechanical ventilation among ventilated children less than12 years of age with Landry Guillain Barre Syndrome who undergo Therapeutic Plasma Exchange (5 Cycles) with those who receive Intravenous Immunoglobulin (@ 2g/kg)
- Secondary Outcome Measures
Name Time Method Adverse Effects of therapy in the two groupsTimepoint: Till discharge/death;All Cause MortalityTimepoint: Till discharge/death;Duration of PICU stayTimepoint: Continuous variable;Functional score (Hughes Score)Timepoint: At PICU discharge, Hospital discharge and 3 months;Healthcare Associated InfectionsTimepoint: Till discharge/death;Time to improvement of one grade in Hughes scoreTimepoint: Continuous variable;Time to walk unaidedTimepoint: Continuous variable