A clinical trial to compare the effect of non-invasive ventilation with high-flow nasal oxygen therapy versus only high flow nasal oxygen therapy in COVID 19 patients with respiratory failure.
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2020/12/029585
- Lead Sponsor
- All India Institute Of Medical Sciences Patna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Adult (Age >18years)
2 Confirmed COVID 19 patients tested positive for SARS-CoV-2 via nasopharyngeal swab by RT-PCR test and admitted to intensive care unit.
3 Acute hypoxemic respiratory failure defined by respiratory rate >=25 breaths/min, and PaO2/FiO2 <=300 mm Hg while spontaneously breathing under standard oxygen therapy.
Exclusion Criteria
Patients will be excluded if PaCO2 above 50 mm Hg, underlying chronic lung disease, cardiogenic pulmonary edema, severe shock, impending cardiopulmonary arrest, Glasgow coma scale score lower than 8 & absence of airway protective gag reflex.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the rates of endotracheal intubation between the two strategies.Timepoint: 28 days
- Secondary Outcome Measures
Name Time Method 1.To compare the mortality rate at day 28 between the two groups. <br/ ><br>2.To observe the ventilator free days (within 28 days). <br/ ><br>3.To observe complications associated with the procedure if any.Timepoint: 28 days