NL-OMON39235
Completed
Not Applicable
Genetic regulation of stress responsivity as a risk factor for schizophrenia and bipolar disorder. ;Subtitle: The association of (epi)genetic factors on the hormonal and autonomic stress response after psychosocial stress - Epistress study
niversitair Medisch Centrum Utrecht0 sites220 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- bipolar I disorder/ manic-depressive illness and schizophrenia
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 220
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Schizophrenia patients (n\=50\)
- •2\. Bipolar I disorder patients (n\=50\)
- •3\. Healthy co\-twin of monozygous twins discordant for bipolar disorder (n\=20\)
- •4\. Healthy volunteers groupwise matched for age, gender, smoking, alcohol use, caffeine intake and drug use (n\=50\)
- •5\. Healthy siblings of bipolar I disorder patients (n\=50\)
Exclusion Criteria
- •General exclusion criteria are:
- •\- speech impairments
- •\- lack of fluency in the Dutch language
- •\- Less than 3 Dutch grand parents;Acute exclusion criteria are:
- •\- any acute illness
- •\- having a severe cold
- •\- recent physical exertion within the last 2 hours
- •\- large meal within the last 2 hours
Outcomes
Primary Outcomes
Not specified
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