BEAT- Beating Egg allergy trial. The effect of early introduction of egg in the diet of high risk for atopic infants and subsequent egg allergy: A prospective randomised double blind cohort study.

Not Applicable

Completed

• Conditions: Egg allergy; Inflammatory and Immune System - Allergies

• Registration Number: ACTRN12611000535976
• Lead Sponsor: Children's Hospital Westmead

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-05-24
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 330

Inclusion Criteria

First degree relative with atopy
<4 months of age

This is the age requirement for recruitment into the study- for the intervention to start at 4-6 months.
Infants can be recruited from birth, but not do not start intervention until they are >4 months old.

Exclusion Criteria

Evidence of IgE sensitization to egg at age 4 months
Unable to complete study requirements
Twin

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IgE sensitisation as measured by skin prick testing to egg at 8 and 12 months af age.[8 months and 12 months of age]

Secondary Outcome Measures

Name	Time	Method
Clinical reactivity to egg (IgE mediated)[study period];IgE sensitisation to other common food allergens (peanut, wheat, soy, milk)[8 and 12 months of age.];Development of doctor diagnosed atopic dermatitis[8 and 12 months of age.];Ovalbumin and Ovomucoid specific IgG4/ IgG1,IgE<br><br>This examines markers of potential tolerance to egg protein with anticipated high IgG4. Evidence of IgE to ovalbumin rather than ovicmucoid- both egg proteins may be markers of likley egg tolerance or sensitisation.[12 months of age]