Safety and Efficacy of Ketamine-Dexmedetomidine versus Ketamind-Propofol Combinations for Sedation in Patients after Coronary Artery Bypass Graft Surgery

Not Applicable

Recruiting

• Conditions: Circulatory System; Coronary Artery Bypass Graft surgery

• Registration Number: PACTR201608001710307
• Lead Sponsor: Tanta Univercity hospital anaesthesia department and Cardiothoracic surgery departement

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients 40-60 years old hemodynamically stable with normal or moderately impaired left ventricular function ejection fraction (EF) > 40%; who underwent elective coronary artery bypass graft surgery under high-dose opioid anesthesia on mechanical ventilation

Exclusion Criteria

-Patient refusal.
-Pregnant patients.
-Patients with neurologic disease
-Patients with liver or renal insufficiency
-Hemodynamic instability both intraoperative, post bypass or postoperative
-Patients on high dose vasopressor or inotropes.
-Patients need muscle relaxant.
-Patients need postoperative mechanical ventilation more than 24 hours.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
compare ketamine-propofol (KP) and ketamine-dexmedetomidine (KD) combinations for sedation and analgesia in patients after coronary artery bypass graft surgery

Secondary Outcome Measures

Name	Time	Method
hemodynamics, total fentanyl dose, duration of mechanical ventilation and any adverse outcome