Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
- Conditions
- General AnesthesiaCoughing ResponseThyroid Surgery
- Interventions
- Drug: DexmeditomidineDrug: normal saline
- Registration Number
- NCT02613806
- Lead Sponsor
- First Affiliated Hospital of Chongqing Medical University
- Brief Summary
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway obstruction due to neck hematoma and increase the need for re-operation.The purpose of this study is to investigate whether dexmedetomidine can reduce the incidence of postoperative coughing and contribute to postoperative recovery in patients undergoing tyroid surgery with general anesthesia.
- Detailed Description
Thyroid surgery is a common clinical surgery,the incidence of postoperative coughing is up to 32.4%.Coughing response could result in postoperative bleeding,even cause respiratory tract obstruction,affect patients' postoperative recovery .Dexmedetomidine,an α2 adrenergic agonist,has hypnotic,analgesic, anxiolytic,antisympathetic effects,which could facilitate the sedation of patients while maintaining their consciousness and keep respiration and circulation stable .For these benefits,dexmedetomidine was widely used for general anesthesia.However,whether dexmedetomidine can reduce the incidence of postoperative coughing is unclear.Therefore,the investigators conduct this randomized controlled double-blind trial,to investigate the effects of dexmedetomidine on coughing and postoperative recovery quality in patients undergoing tyroid surgery with general anesthesia.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 118
- Aged from 18 to 65 years old
- American Society of Anesthesiologists (ASA) physical statusⅠor Ⅱ
- Diagnosed by B ultrasonic or tissue biopsy show that patients thyrophyma,thyroid cancer,thyroid nodule,etc,who need to accept thyroid surgery
- large goiter or hyperthyroidism
- Preoperative coughing caused by primary diseases of patients
- Ⅱdegrees above atrioventricular block
- Allergy to anesthesia
- History of diabetes
- Pregnant women
- Serious mental disease
- History of alcohol or drug abuse
- Severe heart renal or liver dysfunction
- The presence of an upper respiratory infection
- Asthma
- Anticipated difficult airway
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description D group (dexmedetomidine) Dexmeditomidine Dexmeditomidine 0.2 ug/kg·h will be administered to participants by intravenous infusion with microperfusion pump at the beginning of the surgery,and continued till end of surgery. C group (saline) normal saline The patients received equal volume normal saline by intravenous infusion at the beginning of the surgery,and continued till end of surgery.
- Primary Outcome Measures
Name Time Method the incidence of coughing within 48 hours postoperatively coughing will be observed
- Secondary Outcome Measures
Name Time Method the time of extubation within 48 hours postoperatively the time of extubation will be recorded
visual analogue scale (VAS) at 30 minutes after extubation visual analogue scale will be measured at 30 minutes after extubation
coughing on a four-point scale within 48 hours postoperatively coughing on a four-point scale will be measured within 48 hours postoperatively
the eyes opening time within 48 hours postoperatively the eyes opening time will be observed
sedation-agitation scale(SAS) at 30 minutes after extubation sedation-agitation scale will be measured at 30 minutes after extubation
Trial Locations
- Locations (1)
The First Affliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China