Comparing intraoperative opioid consumption in patients who received preemptive oral paracetamol versus no preemptive oral paracetamol in elective cranial surgery.

Completed

• Conditions: Preemptive analgesia as oral paracetamol and intraoperative opioid consumption in elective cranial surgery; Preemptive analgesia; oral paracetamol; intraoperative opioid consumption; cranial surgery; elective surgery

• Registration Number: TCTR20230105001
• Lead Sponsor: /A

Brief Summary

Preemptive oral paracetamol before elective cranial surgery reduces intraoperative fentanyl consumption by 5.1 mcg/hr (p- value 0.02, 95% CI 0.8 to 9.3).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-05
• Study Completion: 2024-06-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 336

Inclusion Criteria

1.Elective cranial surgery patients including craniotomy and craniectomy surgery
2.Age 18-90 years
3.ASA class I-III

Exclusion Criteria

1. Emergency surgery
2. Awake craniotomy
3. Age less than 18 years
4. Use of intraoperative IV paracetamol without preemptive oral paracetamol
5. Use of intraoperative IV lidocaine
6. Use of IV opioid infusion intraoperatively
7. Use of preoperative pain medications
8. Cranial biopsy
9. Transsphenoidal surgery
10. Cranioplasty surgery
11. Pregnant Patients

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
intraoperative opioid consumption including induction till end of surgery fentanyl mcg per hr

Secondary Outcome Measures

Name	Time	Method
hemodynamic changes at intubation at intubation SBP, DBP and heart rate