Paracetamol for postoperative pai

• Conditions: Pain following surgery; MedDRA version: 18.0Level: LLTClassification code 10000683Term: Acute back painSystem Organ Class: 100000004859; MedDRA version: 18.0Level: LLTClassification code 10000690Term: Acute cervical painSystem Organ Class: 100000004859; MedDRA version: 18.0Level: LLTClassification code 10066714Term: Acute painSystem Organ Class: 100000004867; Therapeutic area: Diseases [C] - Symptoms and general pathology [C23]

• Registration Number: EUCTR2015-001562-26-GB
• Lead Sponsor: niversity of Nottingham

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-27
• Last Update Posted: 28 September 2015

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Age 18-80 years old
Elective non-malignant cervical spinal surgery
Capacity to give informed consent
Ability to use PCA device and pain score scale
ASA I, II and III
General anaesthesia
>50kg in weight

Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 25
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 25

Exclusion Criteria

Allergy or sensitivity to paracetamol, proparacetamol or morphine
Liver disease
Renal disease (creatinine clearance <30ml/min)
Bleeding disorder
Chronic alcoholism
Chronic malnutrition
Dehydration
G6PD deficiency
Hypernatraemia (Na >150)
Hypokalaemia (K <3.5) and hyperchloraemia
Pregnancy/breastfeeding

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified