Reproductive function, ovarian reserve and risk of premature menopause in Dutch female childhood cancer survivors
- Conditions
- fertility and ovarian reserve100292091001470110038612
- Registration Number
- NL-OMON31794
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 1250
Inclusion Criteria
Female
Treated for malignancy or a central nervous system tumour before the age of 18
Treated between 1965 and 2001
5-year survivors
At least 18 years at study entry
Exclusion Criteria
For questionnaire:
- survivors who do not speak or read Dutch
- survivors with severe mental sequelae
For the clinical part of the study (blood sample and transvaginal ultrasound)
- females who have had both ovaries removed
- females who are pregnant or lactating at time of study
- females who have not had sexual intercourse are excluded from the ultrasound
measurement
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Sexual activity, childwish at time of completion of the questionnaire, mean<br /><br>time to pregnancy, pregnancy resulting in live birth (yes/no), number of<br /><br>pregnancies, duration of pregnancy, risk of specific adverse pregnancy outcomes<br /><br>(miscarriage, stillbirth), birth weight, age at menopause, age at start of<br /><br>different stages of the menopausal transition, risk of menopause before the age<br /><br>of 40, hormonal levels in blood, uterus volume, and the number of antral<br /><br>follicles as assessed by ultrasound. </p><br>
- Secondary Outcome Measures
Name Time Method <p>n.v.t.</p><br>