euroinflammation in cognitive decline post-cardiac surgery: The FOCUS study - The FOCUS study

Radboud Universitair Medisch Centrum0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•- Patients with cognitive disorders that have not recovered enough to be able to understand the study leaflets and information for participation.
•- Pregnancy or wish to become pregnant within 2 weeks after PET-CT scan
•- Contra-indication to undergo a PET/CT or MRI scan, including claustrophobia.
•- Patients who undergo a combination of CABG surgery and additional valve surgery.
•- Previous cardiac surgery.
•- Low-affinity binder based on rs6971 polymorphism for TSPO, or unable to determine rs6971 polymorphism.
•- Brain or spinal surgery within the last 6 months.
•- Meningitis or brain infection within the last 6 months.
•- Pre-existing dementia or neurodegenerative disease or cognitive impairment interfering with the ability to understand informational material about this research project.
•- Presence of a CSF catheter or shunt.
•- Patients with known brain tumors.
•- Patients with brain injury (e.g. acute stroke, or subarachnoid hemorrhage) within the last 6 months.
•- Severe brain trauma in previous medical history.
•- Chronic (>2 weeks) use of immunosuppressive agents (see table 3.3.A).
•- Concomitant diseases resulting in severe immunosuppression (e.g. HIV).
•- Chronic use of neuroleptics, defined as pre-hospital use.
•- Patients that do not speak Dutch or have disabilities that prevent accurate delirium diagnosis.
•- Analphabetic patients.
•- No written informed consent obtained.

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