Interpretation Bias as a Mechanism of Treatment Response in OCD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obsessive-Compulsive Disorder
- Sponsor
- Mclean Hospital
- Enrollment
- 106
- Locations
- 1
- Primary Endpoint
- Change in Average Score on Yale-Brown Obsessive Compulsive Scale
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I.
Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.
Investigators
Martha J Falkenstein
Director of Research, OCD Institute
Mclean Hospital
Eligibility Criteria
Inclusion Criteria
- •OCD Institute patients
- •adults (\> 18 years old)
- •able to complete a computer task for 20 minutes
- •consent to main OCD Institute study protocol
- •primary diagnosis of OCD (as measured by a score of \>16 on the Y-BOCS and a clinical diagnosis of OCD by their treatment team
- •score of \>131 on the Obsessive Beliefs Questionnaire-44 at admission \[which is 1 SD above the mean score of the non-clinical sample reported in the original validation paper by the Obsessive Compulsive Cognitions Working Group (2005)\]
Exclusion Criteria
- •Currently experiencing acute symptoms of psychosis
- •Psychotic disorder diagnosis
Outcomes
Primary Outcomes
Change in Average Score on Yale-Brown Obsessive Compulsive Scale
Time Frame: Weeks 0, 4, and 8
Interviewer-rated measure of OCD symptoms. It is 19 items, with only items 1-10 scored (from 0-4). Total scores range from 0-40, with higher scores reflecting greater severity.
Secondary Outcomes
- Change in Average Score on Obsessive Beliefs Questionnaire(Time Frame: Weeks 0, 2, 4, and 8)