Value of Whole-body SPECT-CT CzT-based Camera (VERITON-CT) in the Assessment of Chronic Inflammatory Rheumatism With Axial Involvement
- Conditions
- Spondyloarthritis
- Registration Number
- NCT06198361
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The diagnosis of chronic inflammatory rheumatism with axial involvement is not always easy, and is fraught with difficulties : radiological sacroiliitis is not an early sign of spondyloarthritis and the delay in detecting radiological signs contributes to the delay in diagnosis.
Nevertheless, spondyloarthritis is now the second most common chronic inflammatory rheumatic disease, affecting 0.43% of the french population.
The aim of this retrospective study is to evaluate the diagnostic performance of whole-body SPECT-CT CzT-based camera (VERITON-CT) in the assessment of chronic inflammatory rheumatism with axial involvement
MRI of the sacroiliac joints and thoracolumbar spine were used as a gold standard.
- Detailed Description
The present study was conducted by the Department of Rheumatology and Nuclear Medicine of the University Hospital Centre of Nancy (France).
An initial number of 51 hospitalised patients (35 females, 16 males) who underwent SPECT-CT CzT-based camera for polyarthralgia or spinal pain between November 2021 and February 2023 and initial suspicion of chronic inflammatory rheumatism were included in the study.
The investigators retrospectively reviewed the electronic medical records of the consecutive patients using medical softwares (DxCare or VNA Philips). The investigators collected demographic data (age, gender), clinical data (anamnesis, pain level (EVA) and location, standardized clinical activity scores like Ankylosing Spondylitis Disease Activity Score (ASDAS), Widespread Pain Index (WPI), symptom severity scale (SSS)), biological data (protein chain reaction in milligrams per litre), and medical imaging data (X-rays, MRI and CT scans).
The data collected was entered into an Excel spreadsheet protected by a security code.
For medical imaging data, the investigators performed a reading of the sacroiliac and thoracolumbar spine medical imaging under the supervision of an experienced rheumatologist specialising in chronic inflammatory rheumatism.
The investigators assessed the diagnostic performance of VERITON-CT (sensitivity, specificity), using MRI of the sacroiliac joints and thoracolumbar spine as the gold standard.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 47
- Hospitalised patients (hospitalisation sector or day hospital)
- Patients who underwent SPECT-CT CzT-based camera for polyarthralgia or spinal pain between November 2021 and February 2023
- Patients who underwent axial MRI
- Initial suspicion of chronic inflammatory rheumatism
- Patients who did not give their consent
- Patients with extravasation of contrast agent at the injection site
- Patients with a missing phase on SPECT-CT (Blood-Pool phase or Delayed phase)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SI MRI (binary) November 1, 2021 to February 1, 2023 Positives MRI of the sacroiliac joints, according to the ASAS (Assessment of SpondyloArthritis international Society) criteria : binary value
MRI SPARCC (Spondyloarthritis Research Consortium of Canada) Score November 1, 2021 to February 1, 2023 SPARCC scores of the sacroiliac joints and of the thoracolumbar spine in MRI : quantitative value.
Thoraco-lumbar SPARCC score : from 0 to 108, higher scores means worst outcome SI SPARCC score : from 0 to 72, higher scores means worst outcomeSI D phase (binary) November 1, 2021 to February 1, 2023 Positives sacroiliac joints data in VERITON-CT (Delayed phase) : binary value
SI SUV (Standardized Uptake Values) BP phase November 1, 2021 to February 1, 2023 Sum of the SUVs of the sacroiliac joints measured on VERITON-CT (Blood-Pool Phase) : quantitative value
Thoracolumbar SUV (Standardized Uptake Values) BP phase November 1, 2021 to February 1, 2023 Sum of the SUVs of the thoracolumbar spine measured on VERITON-CT (Blood-Pool Phase) : quantitative value
Thoracolumbar SUV D phase November 1, 2021 to February 1, 2023 Sum of the SUVs of the thoracolumbar spine measured on VERITON-CT (Delayed Phase) : quantitative value
Thoracolumbar MRI (binary) November 1, 2021 to February 1, 2023 Positives MRI of the thoracolumbar spine, ≥3 inflammatory discovertebral corners : binary value
Thoracolumbar D phase (binary) November 1, 2021 to February 1, 2023 Positives thoracolumbar spine data in VERITON-CT (Delayed phase) : binary value
SI BP phase (binary) November 1, 2021 to February 1, 2023 Positives sacroiliac joints data in VERITON-CT (Blood-Pool phase) : binary value
SI SUV D phase November 1, 2021 to February 1, 2023 Sum of the SUVs of the sacroiliac joints measured on VERITON-CT (Delayed Phase) : quantitative value
Thoracolumbar BP phase (binary) November 1, 2021 to February 1, 2023 Positives thoracolumbar spine data in VERITON-CT (Blood-Pool phase) : binary value
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Nancy University Hospital
🇫🇷Vandœuvre-lès-Nancy, France
Nancy University Hospital🇫🇷Vandœuvre-lès-Nancy, France