A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis
- Conditions
- NASH - Nonalcoholic Steatohepatitis
- Interventions
- Registration Number
- NCT03900429
- Lead Sponsor
- Madrigal Pharmaceuticals, Inc.
- Brief Summary
A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH and/or reduces fibrosis on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease
- Detailed Description
Primary and secondary endpoint population at Week 52 will be at least 900 patients, more than half fibrosis score 3 (F3), the remainder fibrosis score 2 (F2) and \<10% fibrosis score F1B (F1B) based on final liver biopsy baseline fibrosis score.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1759
-
Must be willing to participate in the study and provide written informed consent.
-
Male and female adults ≥ 18 years of age.
-
Suspected or confirmed diagnosis of NASH fibrosis suggested by the historical data. Meet one of the following criteria that is consistent with NASH liver fibrosis:
- Historical biochemical test for fibrosis: PRO-C3 >14 ng/mL or ELF ≥9
- FibroScan with transient elastography ≥8.5 kPa and controlled attenuation parameter ≥280 dB.m-1
- Historical liver biopsy obtained <2 years before expected randomization showing Stage 1B, 2 or 3 fibrosis with NASH based on existing pathology review, with no significant change in body weight >5% or medication that might affect NAS or fibrosis stage.
-
MRI-PDFF fat fraction ≥8% obtained during the screening period
-
Biopsy-proven NASH (baseline liver biopsy) based on a liver biopsy obtained ≤6 months before anticipated date of randomization (if the biopsy is deemed acceptable for interpretation by the central reader) with fibrosis stage 1A/1C, 1B, 2, or 3 on liver biopsy and NAS of ≥4 with a score of at least 1 in each of the following NAS components:
- Steatosis (scored 0 to 3)
- Ballooning degeneration (scored 0 to 2)
- Lobular inflammation (scored 0 to 3)
-
History of significant alcohol consumption for a period of more than 3 consecutive months within 1 year prior to Screening.
-
Regular use of drugs historically associated with NAFLD
-
Thyroid diseases:
- Active hyperthyroidism.
- Untreated clinical hypothyroidism defined by thyroid stimulating hormone (TSH) >7 IU/L with symptoms of hypothyroidism or >10 IU/L without symptoms.
- Patients who have had a thyroidectomy and are on replacement thyroxine doses >75 µg per day are allowed.
-
History of bariatric surgery or intestinal bypass surgery within the 5 years prior to randomization or planned during the conduct of the study.
-
Recent significant weight gain or loss
-
HbA1c ≥ 9.0%.
-
Glucagon-like peptide 1 [GLP-1] agonist, high dose Vitamin E (> 400 IU/day), or pioglitazone therapy unless stable dose for 24 weeks prior to biopsy.
-
Presence of cirrhosis on liver biopsy defined as stage 4 fibrosis.
-
Diagnosis of hepatocellular carcinoma (HCC).
-
MELD score ≥12, as determined at Screening, unless due to therapeutic anti coagulation.
-
Hepatic decompensation
-
Chronic liver diseases other than NASH
-
Active autoimmune disease
-
Serum ALT > 250 U/L.
-
Active, serious medical disease with a likely life expectancy < 2 years.
-
Participation in an investigational new drug trial in the 60 days or 5 half-lives, whichever is longer.
-
Any other condition which, in the opinion of the Investigator, would impede compliance, hinder completion of the study, compromise the well-being of the patient, or interfere with the study outcomes.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Matching Placebo Liver Biopsy Placebo Daily 80 mg MGL-3196 MGL-3196 80 mg daily 80 mg MGL-3196 Liver Biopsy 80 mg daily 100 mg MGL-3196 MGL-3196 100 mg daily 100 mg MGL-3196 Liver Biopsy 100 mg daily Matching Placebo Placebo Placebo Daily
- Primary Outcome Measures
Name Time Method Week 52 Dual Primary Objectives: To determine the effect of 80 or 100 mg MGL-3196 vs matching placebo on liver biopsy (NASH CRN score) at Week 52 compared with Baseline 52 weeks 1. Proportion with resolution of NASH (ballooning 0, inflammation 0,1) associated with at least 2-point reduction in NAFLD Activity Score (NAS) without worsening of fibrosis stage OR
2. Proportion with at least a 1-point improvement in fibrosis stage with no worsening of NASMonth 54 Primary Objective: Time to experiencing an adjudicated Composite Clinical Outcome event (Final Primary Endpoint, at 54 months) up to 54 months The Composite Clinical Outcome is composed of all-cause mortality, liver transplant, and significant hepatic events (including hepatic decompensation events \[ascites, encephalopathy, or gastroesophageal variceal hemorrhage\], histological progression to cirrhosis, and a confirmed increase of MELD score from \<12 to ≥15).
- Secondary Outcome Measures
Name Time Method Week 52 Key Secondary Objective: To determine the effect of once-daily, oral administration of MGL-3196 80 or 100 mg versus matching placebo on the percent change from Baseline at 24 weeks in directly measured low-density lipoprotein cholesterol (LDL-C) 24 weeks Assess the effect of MGL-3196 80 mg or 100 mg compared to placebo on LDL-C measured by percent change from Baseline at 24 weeks.
Trial Locations
- Locations (244)
Toronto Liver Center
🇨🇦Toronto, Ontario, Canada
Florida Research Institute
🇺🇸Lakewood Ranch, Florida, United States
GI Specialists of Georgia
🇺🇸Marietta, Georgia, United States
The Liver Institute at Methodist Dallas Medical Center
🇺🇸Dallas, Texas, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
Bioclinica Research - The Villages
🇺🇸The Villages, Florida, United States
Mt. Sinai Medical Center
🇺🇸New York, New York, United States
Associates in Gastroenterology
🇺🇸Hermitage, Tennessee, United States
Pinnacle Clinical Research - Austin
🇺🇸Rollingwood, Texas, United States
Cumberland Research Associates
🇺🇸Fayetteville, North Carolina, United States
University of North Carolina Medical Center - Chapel Hill
🇺🇸Charlotte, North Carolina, United States
Salt Lake City Research Center
🇺🇸Murray, Utah, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
South Texas Research Institute - Brownsville
🇺🇸Brownsville, Texas, United States
Dallas Research Center
🇺🇸Dallas, Texas, United States
Texas Digestive Disease Consultants - Dallas
🇺🇸Dallas, Texas, United States
Texas Digestive Disease Consultants - Gastroenterology Associates - Baton Rouge
🇺🇸Baton Rouge, Louisiana, United States
South Texas Research Institute
🇺🇸Edinburg, Texas, United States
Doctor's Hospital at Renaissance
🇺🇸McAllen, Texas, United States
Texas Digestive Disease Consultants - San Marcos
🇺🇸San Marcos, Texas, United States
Consultants for Clinical Research
🇺🇸Cincinnati, Ohio, United States
Clinical Research US - Henderson
🇺🇸Henderson, Nevada, United States
Plano Research Center
🇺🇸Plano, Texas, United States
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Premier Medical Group - Clarksville
🇺🇸Clarksville, Tennessee, United States
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Gastrointestinal Associates and Endoscopy Center - Madison
🇺🇸Flowood, Mississippi, United States
Mater Misericordiae
🇦🇺South Brisbane, Queensland, Australia
Wasatch Peak Family Practice
🇺🇸Layton, Utah, United States
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Gastro One - Germantown - Centre Oak Way
🇺🇸Germantown, Tennessee, United States
Lucas Research
🇺🇸Morehead City, North Carolina, United States
Saint Vincent's Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
Centre Hospitalier Universitaire Henri Mondor
🇫🇷Créteil Cedex, Ile-de-France, France
Monash Medical Centre
🇦🇺Clayton, Victoria, Australia
Universitätsklinikum Würzburg
🇩🇪Würzburg, Germany
Universitätsklinikum St. Pölten
🇦🇹St. Pölten, Austria
Soroka University Medical Center
🇮🇱Be'er Sheva, Israel
John Hunter Hospital
🇦🇺New Lambton, New South Wales, Australia
Lair Centre
🇨🇦Vancouver, Canada
University of Alberta
🇨🇦Edmonton, Alberta, Canada
University of Calgary Liver Unit
🇨🇦Calgary, Alberta, Canada
Centre Hospitalier Universitaire Estaing
🇫🇷Clermont-Ferrand, Auvergne, France
Universitair Ziekenhuis Brussel
🇧🇪Brussel, Belgium
Charité Universitätsmedizin Berlin - Campus Mitte
🇩🇪Berlin, Germany
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Medizinische Universität Wien
🇦🇹Vienna, Austria
Charité Universitätsmedizin Berlin
🇩🇪Berlin, Germany
William Osler Health System
🇨🇦Brampton, Ontario, Canada
Magyarország Egészségügyi Szolgáltató - Gyula
🇭🇺Gyula, Bekes, Hungary
Azienda Ospedaliero - Universitaria Careggi
🇮🇹Firenze, Italy
Leipzig Research Center
🇩🇪Leipzig, Germany
Hôpital Beaujon
🇫🇷Clichy, France
Frankfurt Clinical Research Center
🇩🇪Frankfurt am main, Germany
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Tel Aviv, Israel
Rabin Medical Center
🇮🇱Petah Tikva, Israel
Centrum Medyczne Pratia Poznan
🇵🇱Skórzewo, Poland
Azienda Ospedaliera Universitaria Policlinico Gaetano Martino
🇮🇹Messina, Italy
The Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Universitätsmedizin der Johannes Gutenberg Universität Mainz
🇩🇪Mainz, Germany
Emek Medical Center
🇮🇱Afula, Israel
Fondazione Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
Universitätsklinikum des Saarlandes
🇩🇪Homburg, Germany
Fundación De Investigación De Diego
🇵🇷San Juan, Puerto Rico
Azienda Ospedaliera Papa Giovanni XXIII
🇮🇹Bergamo, Italy
EUGASTRO
🇩🇪Leipzig, Germany
Hospital de la Santa Creu i de Sant Pau
🇪🇸Barcelona, Spain
SIBAmed Studienzentrum
🇩🇪Leipzig, Germany
Rambam Health Care Campus - Rambam Medical Center
🇮🇱Haifa, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Hospital Universitari Vall d'Hebrón
🇪🇸Barcelona, Spain
Ospedale Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Italy
Complejo Hospitalario Torrecárdenas
🇪🇸Almeria, Spain
Hospital del Mar - Parc de Salut Mar
🇪🇸Barcelona, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Universitatsspital Zurich
🇨🇭Zürich, Switzerland
Saint George's University Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
Consorci Hospital General Universitari de València
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸Valencia, Spain
The Hexham Clinic
🇬🇧Hexham, Northumberland, England, United Kingdom
Abertawe Bro Morgannwg University Health Board
🇬🇧Swansea, Wales, United Kingdom
Plymouth Hospitals NHS Trust
🇬🇧Plymouth, United Kingdom
Northwestern Medical Faculty Foundation
🇺🇸Chicago, Illinois, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Liver Associates of Texas
🇺🇸Houston, Texas, United States
Kansas Medical Clinic - Gastroenterology
🇺🇸Topeka, Kansas, United States
Royal Perth Hospital
🇦🇺Perth, Western Australia, Australia
University of Kansas Medical Center Research Institute
🇺🇸Fairway, Kansas, United States
Klinikum Klagenfurt Am Wörthersee
🇦🇹Klagenfurt, Carinthia, Austria
New York Presbyterian Hospital
🇺🇸New York, New York, United States
Barts Health NHS Trust
🇬🇧London, England, United Kingdom
University of Miami
🇺🇸Miami, Florida, United States
Miami Dade Medical Research Institute
🇺🇸Miami, Florida, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
The Texas Liver Institute
🇺🇸San Antonio, Texas, United States
San Antonio Research Center
🇺🇸San Antonio, Texas, United States
University of Utah Hospital
🇺🇸Salt Lake City, Utah, United States
Landesklinik St. Veit
🇦🇹Salzburg, Austria
Algemeen Ziekenhuis Maria Middelares
🇧🇪Gent, Oost-Vlaanderen, Belgium
Polska Oddział w Częstochowie
🇵🇱Częstochowa, Poland
Universitair Ziekenhuis Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
Centre Hospitalier Universitaire Brugmann
🇧🇪Laeken, Belgium
McMaster University
🇨🇦Hamilton, Ontario, Canada
AZ Delta Campus Wilgenstraat
🇧🇪Roeselare, West-Vlaanderen, Belgium
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház
🇭🇺Nyíregyháza, Szabolcs-Szatmar-Bereg, Hungary
Centro Mexicano de Desarrollo de Estudios Clínicos
🇲🇽Ciudad de México, Distrito Federal, Mexico
Investigaciones Médicas Cisneros
🇲🇽Monterrey, Nuevo Leon, Mexico
Krankenanstalt Rudolfstiftung
🇦🇹Wien, Vienna, Austria
JM Research
🇲🇽Cuernavaca, Morelos, Mexico
Debreceni Egyetem Kenézy Gyula Egyetemi Kórház
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Fondazione Epatocentro Ticino
🇨🇭Lugano, Switzerland
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Centre Hospitalier Universitaire de Rennes
🇫🇷Rennes Cedex 9, Bretagne, France
Hôpital Erasme
🇧🇪Bruxelles, Brussels, Belgium
Nouvel Hôpital Civil
🇫🇷Strasbourg Cedex, Alsace, France
Centro Integral en Reumatología
🇲🇽Guadalajara, Jalisco, Mexico
Les Hôpitaux Universitaires de Strasbourg - Hôpital Hautepierre
🇫🇷Strasbourg, Alsace, France
Midlands Clinical Research Centre
🇬🇧Birmingham, England, United Kingdom
Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
🇭🇺Budapest, Hungary
Polska Oddział w Gdansk
🇵🇱Gdańsk, Poland
Polska Oddział w Poznaniu
🇵🇱Poznań, Poland
Polska Oddział w Wrocław
🇵🇱Wrocław, Poland
Polska Oddział w Łodz
🇵🇱Łódź, Poland
Polska Oddział w Katowicach
🇵🇱Katowice, Poland
Chelsea and Westminster Hospital NHS Foundation Trust
🇬🇧London, England, United Kingdom
Imperial College Healthcare NHS Trust
🇬🇧London, England, United Kingdom
Universitatsspital Bern
🇨🇭Bern, Switzerland
North Teesside Clinical Research Centre
🇬🇧Hardwick, England, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
🇬🇧Birmingham, England, United Kingdom
Lancashire Clinical Research Centre
🇬🇧Chorley, England, United Kingdom
Merseyside Clinical Research Centre
🇬🇧Liverpool, England, United Kingdom
Manchester Clinical Research Centre
🇬🇧Manchester, England, United Kingdom
Portsmouth Hospitals NHS Trust
🇬🇧Portsmouth, United Kingdom
Nottingham University Hospitals NHS Trust
🇬🇧Nottingham, England, United Kingdom
Norfolk and Norwich University Hospital
🇬🇧Norwich, England, United Kingdom
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Polo Universitario - L'Azienda Ospedaliera Luigi Sacco
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria-Maggiore della Carità di Novara
🇮🇹Novara, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
🇮🇹Palermo, Italy
Hôpital Jean-Minjoz
🇫🇷Besançon, Franche-Comte, France
Hôpital Avicenne
🇫🇷Bobigny Cedex, Ile-de-France, France
Centre Hospitalier Universitaire de Montpellier
🇫🇷Montpellier Cedex 5, Languedoc-Roussillon, France
Hôpital de la Croix Rousse
🇫🇷Lyon Cedex 04, Rhone-Alpes, France
Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois
🇫🇷Vandœuvre-lès-Nancy, France
Centre Hospitalier Régional Universitaire de Lille
🇫🇷Lille, Nord Pas-de-Calais, France
Centre Hospitalier Universitaire de Nice Hôpital l'Archet
🇫🇷Nice Cedex 3, Provence Alpes Cote D'Azur, France
Hôpital Universitaire Pitié Salpêtrière
🇫🇷Paris Cedex 13, France
Centre Hospitalier Universitaire Amiens-Picardie
🇫🇷Amiens, France
Toronto General Hospital - Clinical Trials Pharmacy
🇨🇦Toronto, Ontario, Canada
Complejo Hospitalario de Pontevedra
🇪🇸Pontevedra, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Gastrointestinal Associates - Knoxville
🇺🇸Knoxville, Tennessee, United States
Adobe Gastroenterology
🇺🇸Tucson, Arizona, United States
The Institute for Liver Health - Chandler
🇺🇸Chandler, Arizona, United States
Desert Clinical Research
🇺🇸Mesa, Arizona, United States
The Institute for Liver Health - Glendale
🇺🇸Glendale, Arizona, United States
Arkansas Gastroenterology
🇺🇸North Little Rock, Arkansas, United States
Fresno Clinical Research Center
🇺🇸Fresno, California, United States
National Research Institute - Huntington Park
🇺🇸Huntington Park, California, United States
University of California San Diego
🇺🇸La Jolla, California, United States
East Valley Family Physicians
🇺🇸Chandler, Arizona, United States
Stanford University School of Medicine
🇺🇸Palo Alto, California, United States
National Research Institute - Panorama City
🇺🇸Panorama City, California, United States
San Fernando Valley Health Institute
🇺🇸Van Nuys, California, United States
Colorado Springs Family Practice
🇺🇸Colorado Springs, Colorado, United States
South Denver Gastroenterology - Swedish Medical Center Office
🇺🇸Englewood, Colorado, United States
Alliance Clinical Research
🇺🇸Poway, California, United States
Excel Medical Clinical Trials
🇺🇸Boca Raton, Florida, United States
Covenant Metabolic Specialists - Fort Myers
🇺🇸Fort Myers, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Clinical Research - Chicago
🇺🇸Chicago, Illinois, United States
The University of Chicago Medicine
🇺🇸Chicago, Illinois, United States
Covenant Research
🇺🇸Sarasota, Florida, United States
Clinical Trials of America
🇺🇸West Monroe, Louisiana, United States
Southern Therapy and Advanced Research
🇺🇸Jackson, Mississippi, United States
Aventiv Research - Columbus
🇺🇸Columbus, Ohio, United States
Brooke Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Impact Research Institute
🇺🇸Waco, Texas, United States
Liver Institute Northwest
🇺🇸Seattle, Washington, United States
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Sir Charles Gairdner Hospital
🇦🇺Nedlands, Western Australia, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Ordensklinikum Linz GmbH Barmherzige Schwestern
🇦🇹Linz, Upper Austria, Austria
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Antwerpen, Belgium
Klinikum Wels-Grieskirchen
🇦🇹Wels, Austria
Universitair Ziekenhuis Leuven
🇧🇪Leuven, Belgium
Ziekenhuis Oost-Limburg'
🇧🇪Genk, Limburg, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
South Shore Medical Arts
🇨🇦Bridgewater, Nova Scotia, Canada
LMC/ Manna Research - Brampton
🇨🇦Brampton, Ontario, Canada
Assistance Publique-Hôpitaux de Paris Hôpital Cochin
🇫🇷Paris Cedex 14, Ile-de-France, France
Hôpital Dupuytren
🇫🇷Limoges, Limousin, France
Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
🇫🇷Toulouse Cedex, Midi-Pyrenees, France
Center Hospitalier Universitaire d'Angers
🇫🇷Angers, Pays De La Loire, France
Berlin Clinical Research Center
🇩🇪Berlin, Germany
EPIMED
🇩🇪Berlin, Germany
Zentrum für Infektiologie Berlin Prenzlauer Berg
🇩🇪Berlin, Germany
Universitätsklinikum Frankfurt
🇩🇪Frankfurt am main, Germany
Magyarország Research Center
🇭🇺Budapest, Hungary
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
🇭🇺Békéscsaba, Bekes, Hungary
Hadassah University Hospital Ein Kerem
🇮🇱Jerusalem, Israel
Western Galilee Hospital-Nahariya
🇮🇱Nahariya, Israel
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
🇮🇹Palermo, Italy
Azienda Ospedaliero-Universitaria Pisana Ospedale Cisanello
🇮🇹Pisa, Italy
Universita degli Studi di Roma La Sapienza - Umberto I Policlinico di Roma
🇮🇹Roma, Italy
Centro de Investigacion y Gastroenterologia
🇲🇽Ciudad de México, Distrito Federal, Mexico
Polska Oddział w Gdyni
🇵🇱Gdynia, Poland
Polska Oddział w Warszawie
🇵🇱Warszawa, Poland
Hospital Universitario Puerta de Hierro - Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Awasty Research Network
🇺🇸Marion, Ohio, United States
Texas Digestive Disease Consultants - Bay Area Gastroenterology
🇺🇸Webster, Texas, United States
GI Research Institute
🇨🇦Vancouver, Canada
Texas Digestive Disease Consultants - Fort Worth
🇺🇸Fort Worth, Texas, United States
Hospital Universitario Ramón Y Cajal
🇪🇸Madrid, Spain
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
Ruane Clinical Research
🇺🇸Los Angeles, California, United States
The Institute for Liver Health - Tucson
🇺🇸Tucson, Arizona, United States
National Research Institute - Los Angeles
🇺🇸Los Angeles, California, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
Holy Family Hospital
🇮🇱Nazareth, Israel
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
🇬🇧Newcastle Upon Tyne, England, United Kingdom
Aintree University Hospitals NHS Foundation Trust
🇬🇧Liverpool, United Kingdom
Thames Valley Dedicated Research Centre
🇬🇧Reading, England, United Kingdom
Liver Center of Texas
🇺🇸Dallas, Texas, United States
University of Florida Hepatology Research at CTRB
🇺🇸Gainesville, Florida, United States
Bioclinica Research - Orlando
🇺🇸Orlando, Florida, United States
Tulane University School of Medicine
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center
🇺🇸New Orleans, Louisiana, United States
Walter Reed National Military Medical Center
🇺🇸Bethesda, Maryland, United States
Saint Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
Kansas City Research Institute
🇺🇸Kansas City, Missouri, United States
Bon Secours St. Mary's Hospital of Richmond
🇺🇸Richmond, Virginia, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
Hunter Holmes McGuire Veterans Administration Medical Center
🇺🇸Richmond, Virginia, United States
Cambridge University Hospitals NHS Foundation Trust
🇬🇧Cambridge, England, United Kingdom
The Wales Clinic
🇬🇧Cardiff, Wales, United Kingdom
Royal Free London NHS Foundation Trust
🇬🇧London, England, United Kingdom
Belfast Health and Social Care Trust
🇬🇧Belfast, Northern Ireland, United Kingdom