Serum D dimer and Procalcitonin Levels at Admission as Predictors of Severity in patients with Acute Pancreatitis

Not yet recruiting

Brief Summary: This prospective observational cohort study aims to assessthe predictive value of serum D-dimer and procalcitonin levels at admission indetermining the severity of acute pancreatitis (AP). The study will includeadult patients (18–70 years) presenting within 24 hours of symptom onset. TheRevised Atlanta Classification and Modified Marshall Scoring System will beused to classify AP severity and assess organ dysfunction. Given the associationsof AP with systemic inflammation, sepsis, and microvascular thrombosis,procalcitonin and D-dimer levels may serve as early biomarkers for severityassessment. A total of 62 patients will be recruited, accounting for a 10%dropout rate. Blood samples will be collected at admission for D-dimer andprocalcitonin measurements. Patients will be monitored for up to 8 days oruntil discharge for development of complications, organ failure, and outcomes.Data will be analysed using SPSS, with ROC curve analysis to evaluate thepredictive accuracy of both biomarkers. Multiple regression will identifyindependent predictors of severity and mortality. The study seeks to establishwhether these biomarkers can aid in early risk stratification and guideclinical decision-making in acute pancreatitis.

Recruitment & Eligibility

Inclusion Criteria

Adult patients (18-70 years) with acute pancreatitis presenting within 24 hrs of symptom onset.

Exclusion Criteria

1.Pregnancy.
2.Patients presenting more than 24 hours of symptom onset.
3.Chronic pancreatitis 4.Recurrent pancreatitis 5.Age less than 18 years old or over 70 years old 6.Anticoagulant drug use 7.Cancer 8.Thrombotic diseases 9.Liver cirrhosis 10.Patient on immunosuppressive therapy 11.Refusal to give consent.

Primary Outcome Measures

Name	Time	Method
1.To determine if serum D-dimer and procalcitonin levels at the time of admission can predict the severity of acute pancreatitis.	Preparation and ethical approval-1-2 months \| Data collection- 3 months \| Data analysis, reporting and dissemination:1 month

Secondary Outcome Measures

Name	Time	Method
2.To evaluate whether D-dimer and procalcitonin levels are associated with the development of complications and mortality in patients with acute pancreatitis.	3.To determine the most reliable predictor between D-dimer and procalcitonin for early risk assessment in Acute Pancreatitis patients.

Locations (1): All India Institute of Medical Sciences Kalyani
🇮🇳
Nadia, WEST BENGAL, India
All India Institute of Medical Sciences Kalyani
🇮🇳Nadia, WEST BENGAL, India
Dr Biswajit Naskar
Principal investigator
6290074738
mynameisjit310789@gmail.com