Nicardipine Versus Labetalol During Intubation

Not Applicable

• Conditions: Patients Who Are Intubated for General Anesthesia; Endotracheal Intubation
• Interventions: Drug: nicardipine; Drug: labetalol

• Registration Number: NCT01041066
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-09
• Study Start: 2009-09
• Primary Completion: 2009-12
• Study First Submitted: 2009-12-30
• Study First Submitted QC: 2009-12-30
• Last Update Submitted: 2009-12-30
• Study First Posted: 2009-12-31
• Last Update Posted: 2009-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria

• Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group N	nicardipine	20 ㎍/kg nicardipine
group L	labetalol	0.4 mg/kg labetalol

Primary Outcome Measures

Name	Time	Method
hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate)	preinduction- 10 min after intubation

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of