A protein fingerprint of postoperative pain in the human incision model under controlled conditions
Not Applicable
Recruiting
- Conditions
- Postoperative painPain as diease
- Registration Number
- DRKS00016641
- Lead Sponsor
- niversitätsklinik Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 26
Inclusion Criteria
Male, Age 18-40, healthy, unremarkable QST report
Exclusion Criteria
Age over 40, pre-existing conditions (diabetes m .; cardiac pre-existing conditions, pruritus, skin diseases (arm), neurological diseases, medication intake, regular analgesic intake <3 days before experiment, conspicuous QST, chronic medication intake and pre-existing pain or chronic diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of proteome (24 hours after incision) via mass spectroscopy from skin and blood samples for incision-related pain in a human surrogate model for postoperative pain.
- Secondary Outcome Measures
Name Time Method 1. Identification and correlation of candidate proteins that are more regulated in subjects with a large secondary hyperalgesia area after experimental incision than in subjects with a small secondary hyperalgesia area<br>2. What differences and similarities can be found between human and animal (mouse) in a comparable trauma in the proteome of skin and blood samples?