The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children
- Conditions
- Inguinal Hernia
- Interventions
- Registration Number
- NCT02646709
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
Rocuronium is suitable for rapid induction within 60-90 seconds and its effect last 24-40 minute after single bolus injection. For outpatient surgery with short operation time, low dose rocuronium is frequently used for rapid recovery at the expense of compromised intubating condition. For better intubating condition, ketamine can be used. However, appropriate dose of ketamine with low dose rocuronium is not established yet. This study, 3 different doses of ketamine with low dose rocuronium will be compared for appropriate intubating condition.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- ASA class I, II
- upper respiratory infection within 14 days
- anticipated difficult intubation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ketamine 1 ketamine 1 Ketamine 1 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation. Ketamine 2 Rocuronium Ketamine 2 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation. Ketamine 2 ketamine 2 Ketamine 2 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation. Ketamine 1.5 ketamine 1.5 Ketamine 1.5 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation. Ketamine 1.5 Rocuronium Ketamine 1.5 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation. Ketamine 1 Rocuronium Ketamine 1 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation.
- Primary Outcome Measures
Name Time Method Intubation Condition during and after intubation, about 2 minute 5 variables will be individually evaluated though 3 point scale (excellent, good, poor). If all variables are graded as excellent, intubation condition will be excellent. If at least 1 variable is poor, it will be reported as poor. Otherwise, it will be reported as good.
1. Laryngoscope easiness
2. Vocal cord position
3. Vocal cord movement
4. Movement of limb
5. Coughing
- Secondary Outcome Measures
Name Time Method heart rate 1. 1 min before induction 2.1 min after ketamine injection 3. 1min after intubation 4. 5 min after intubation 5. 10 min after intubation heart rate will be recorded.
time for extubation from the end of surgery to extubation, within 10 min emergence agitation (4 points scale) 5 min after postanesthesia care unit (PACU) admission 4 points scale
1: calm 2. cry but manageable 3. cry, not manageable 4. excitationPACU time from PACU admission to discharge, about 30 min severity of vomiting 1. 1 min after PACU admission 2. 30 min after PACU admission severity(0-10)
Analgesic requirements (mg/kg) during PACU stay, about 30 min if pain score exceed 3, fentanyl will be introduced. The total dose of fentanyl injection will be recorded.
Desaturation during PACU stay, about 30 min pulseoximeter will be applied and peripheral oxygen saturation less than 94 will be recorded.
blood pressure 1. 1 min before induction 2.1 min after ketamine injection 3. 1min after intubation 4. 5 min after intubation 5. 10 min after intubation blood pressure will be recorded
frequency of vomiting 1. 1 min after PACU admission 2. 30 min after PACU admission