Adjunctive Dexmedetomidine Infusion in Non-intubated Video-assisted Thoracoscopic Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 144
- 试验地点
- 2
- 主要终点
- Cough
研究概览
简要总结
This prospective study aims to evaluate the effectiveness of intraoperative DEX for postoperative analgesia and recovery after non-intubated VATS. In addition, the investigators observe the impact of DEX on anesthetic requirements, hemodynamic parameters, and adverse events during non-intubated VATS.
详细描述
The non-intubated thoracoscopic approach has been adapted for use with major lung resections. The non-intubated VATS tries to minimize the adverse effects of tracheal intubation and general anesthesia, such as intubation-related airway trauma, ventilation-induced lung injury, residual neuromuscular blockade, and postoperative nausea and vomiting. An adequate analgesia allows VATS to be performed in sedated patients and the potential adverse effects related to general anesthesia and selective ventilation can be avoided. Dexmedetomidine (DEX), a highly selective alpha-2 receptor agonist, is increasingly used in anesthesia with sedative, hypnotic, anxiolytic, sympatholytic, and analgesic effects. It can also attenuate perioperative stress and inflammation and preserve the immunity of surgical patients, which may contribute to reduced postoperative complications and improved clinical outcomes. This study aims to evaluate the effectiveness of intraoperative DEX for postoperative analgesia and recovery after non-intubated VATS. In addition, the investigators observe the impact of DEX on anesthetic requirements, hemodynamic parameters, and adverse events during non-intubated VATS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) score of I-III patients receiving video-assisted thoracoscopic surgery
排除标准
- •Age < 18 or > 80 years
- •ASA classifications > III
- •Pregnancy
- •Known allergies to any drugs used in the study
- •Emergency surgery
- •Patient refusal
- •Chronic pain history
研究组 & 干预措施
Group Saline
Propofol-based total intravenous anesthesia with saline infusion
干预措施: Dexmedetomidine infusion (Drug)
Group Dexmedetomidine
Propofol-based total intravenous anesthesia with dexmedetomidine infusion
干预措施: Dexmedetomidine infusion (Drug)
结局指标
主要结局
Cough
时间窗: Intraoperative period
The incidence of cough reflex during surgery and severity Cough severity: 1=none, 2=slight, 3=moderate, 4=severe
次要结局
- Total fentanyl consumption(Intraoperative period)
- Intraoperative fentanyl consumption(Intraoperative period)
- Total propofol consumption(Intraoperative period)
- Intraoperative adverse events(Intraoperative period)
- Postoperative opioid requirement(Postoperative 48 hours)
- Postoperative numeric rating scale(Postoperative 48 hours)
研究者
Wei-Cheng Tseng
Principal Investigator
Tri-Service General Hospital