Intermittent furosemide therapy as a prophylaxis of acute renal failure in CABG patients
- Conditions
- Coronary artery disease.Atherosclerotic heart disease
- Registration Number
- IRCT201502122804N8
- Lead Sponsor
- Vice chancellor for research, Shahid Rajaei Heart Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 123
age 40-75;
elective CABG with CPB;
constant surgeon;
informed written consent;
Exclusion criteria:
old age above 75 years;
emergency surgery;
high risk surgery;
ischemic heart disease;
diabetes mellitus;
diabetic ketoacidosis;
non-ketonic hyperosmolar diabetic coma;
acute renal failure;
chronic kidney disease causing serum Cr>2mg/dL;
glomerulonephritis;
hepatic failure causing liver function test failure (> 3 times than normal);
off pump CABG;
any unwanted complication in the operation period;
re-starting CPB after weaning from bypass;
pulmonary artery pressure >30 before operation;
ejection fraction<30%;
re-operation in the postoperative period;
congestive heart failure;
thyroid disorders;
acute infections;
stroke;
pregnancy;
hospital admission in the recent 3 months;
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative serum markers of renal function including Glomerular Filtration Rate (GFR). Timepoint: Preoperative levels and also early postoperative period (mainly 24 hours). Method of measurement: level of serum markers; then using the Cockcroft-Gault formula.
- Secondary Outcome Measures
Name Time Method Acid-base and electrolytes of the plasma. Timepoint: before the intervention and 24 hours after intervention. Method of measurement: serum levels of markers.