Heart Failure-USB: Prediction and Progression

Recruiting

• Conditions: Acute Heart Failure; Acute Coronary Syndrome; Heart Failure
• Interventions: Other: medical chart review; Other: data generated by direct IT export

• Registration Number: NCT04000061
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-13
• Study First Submitted: 2019-06-25
• Study First Submitted QC: 2019-06-25
• Study First Posted: 2019-06-27
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-10
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

• Patients hospitalized with a primary diagnosis of ACS
• Patients hospitalized with a primary or secondary diagnosis of AHF

Exclusion Criteria

• Existence of a documented statement of the patient against the scientific use of clinical data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
acute heart failure (AHF)	data generated by direct IT export	Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed.
acute coronary syndrome (ACS)	medical chart review	Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed.
acute coronary syndrome (ACS)	data generated by direct IT export	Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed.
acute heart failure (AHF)	medical chart review	Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed.

Primary Outcome Measures

Name	Time	Method
number of all-cause death	1 to 8 years after hospitalization	number of all-cause death in patients hospitalized with ACS and AHF during the years 2010-2023.
number of cardiovascular hospitalizations	1 to 8 years after hospitalization	number of cardiovascular hospitalizations
number of HF hospitalizations	1 to 8 years after hospitalization	number of new HF hospitalizations in patients hospitalized with ACS and AHF during the years 2010-2023
number of cardiovascular death	1 to 8 years after hospitalization	number of cardiovascular death in patients hospitalized with ACS and AHF

Trial Locations

Locations (1)

Cardiology, University Hospital Basel; 🇨🇭 Basel, Switzerland