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Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex

Phase 4
Withdrawn
Conditions
Neuromuscular Blockade
Interventions
Drug: Normal saline
Registration Number
NCT02562417
Lead Sponsor
Centre Hospitalier Universitaire Vaudois
Brief Summary

Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting. Recent animal data have shown that dexamethasone may impair the reversal effect of sugammadex. The objective of this randomised controlled trial is to confirm in the clinical practice these preliminary results.

Detailed Description

Not available

Recruitment & Eligibility

Status
WITHDRAWN
Sex
All
Target Recruitment
Not specified
Inclusion Criteria
  • patients scheduled to undergo microlaryngoscopy and ear-nose-throat endoscopic procedures
Exclusion Criteria
  • contraindication to dexamethasone administration
  • contraindication to sugammadex administration
  • contraindication to rocuronium administration

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
IV dexamethasoneIV dexamethasonePatients will receive 0.1 mg/kg of dexamethasone.
No IV dexamethasoneNormal salinePatients will receive an equivalent volume of normal saline.
Primary Outcome Measures
NameTimeMethod
Mean recovery time for T4/T1 ratio > 90% after sugammadex administrationsurgical procedure
Secondary Outcome Measures
NameTimeMethod
Mean recovery time for T4/T1 ratio > 70% after sugammadex administrationsurgical procedure
Mean recovery time for T4/T1 ratio > 80% after sugammadex administrationsurgical procedure

Trial Locations

Locations (1)

Lausanne University Hospital

🇨🇭

Lausanne, VAud, Switzerland

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