Multiplate-Analysis as prognostic marker in cerebral hemorrhage

• Conditions: Intracerebral hemorrhageSubdural hemorrhageSubarachnoidal hemorrhage; I61; I62; I60; Intracerebral haemorrhage; Other nontraumatic intracranial haemorrhage; Subarachnoid haemorrhage

• Registration Number: DRKS00021725
• Lead Sponsor: niversitätsklinikum der RWTH Aachen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Signed declaration of consent + blood samples
- Age over 18 years
- proven intracerebral hemorrhage (CT/MRT)
- Ingestion of at least 1 platelet function inhibitor (test group)
- Unequivocal understanding of the information provided about the study

Exclusion Criteria

- No image correlate of the initial neurological symptoms
- Competing prognostic factors at the onset of symptoms: e.g. medication, metabolic derailments, sepsis
- Persons who are in a dependency / employment relationship with one of the investigators
- Minority
- Pregnancy and breastfeeding
- People who are accommodated in an institution by order of a court or an official
- Simultaneous participation in a clinical study
- unwilling or unable to understand the instructions of the staff or to obey them
- incapable of giving consent and / or are unable to understand the nature, significance and scope of the research project and to give their consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progress of the bleeding<br><br>Procedure:<br>1)<br>Comparison of the size of the bleeding between the CAT-Scan at admission and the follow-up CAT-Scan (24-48 hours later) in both arms (measurement of the bleeding size in the program for image processing used by the department of neuroradiology)<br><br>2)<br>Statistical evaluation if there was a significant difference in bleeding enlargement between the group with pre-existing antiplatelet therapy and the group without pre-existing antiplatelet therapy

Secondary Outcome Measures

Name	Time	Method
therapy failure<br><br>-> number of patients with pre-existing antiplatelet therapy but insufficient score in the Multiplate-analysis