Risk Factors And Outcomes Of Hospital Acquired AKI

Completed

• Conditions: AKI - Acute Kidney Injury
• Interventions: Other: standard care for hospitalized patients; Other: standard AKI care bundle

• Registration Number: NCT06051708
• Lead Sponsor: Alexandria University

Brief Summary

The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.

Detailed Description

Hospital-acquired AKI (HAAKI) is defined as acute renal insult occurring 48 hours or more after admission to a health care facility and It is estimated to occur in 13-18% of hospitalized patients. The early diagnosis of HAAKI reflects on improvement in morbidity and mortality rates especially in developing countries which goes parallel with the goal The International Society of Nephrology (ISN) to eliminate preventable or treatable deaths from AKI by 2025, the "0 by 25" initiative.

Data concerning the spectrum of acute kidney injury (AKI) in Egypt are generally scarce.

Study Timeline

• Study Start: 2023-06-01
• Study First Submitted: 2023-09-17
• Study First Submitted QC: 2023-09-21
• Study First Posted: 2023-09-25
• Primary Completion: 2024-04-01
• Study Completion: 2024-05-15
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-15
• Last Update Posted: 2024-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

1. Fulfilment of definition of acute kidney injury according to KDIGO reference.
2. Age more than 18 years.

Exclusion Criteria

1. Mentally or physically unfit patients.
2. Patients who developed acute kidney injury within 48 hours of admission to hospital.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
no AKI group	standard care for hospitalized patients	patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge
AKI group	standard AKI care bundle	patients who are hospitalized and develop acute kidney injury after 48 hours from admission

Primary Outcome Measures

Name	Time	Method
Recovery of kidney functions	12 weeks	(improvement of eGFR, serum creatinine to normal or previous baseline).

Secondary Outcome Measures

Name	Time	Method
Need for renal replacement therapy	12 weeks	different modalities of RRT
mortality	12 weeks	death
progression to chronic kidney disease.	12 weeks	deterioration of kidney functions ( creatinine, eGFR)

Trial Locations

Locations (1)

Faculty of Medicine, Aexandria University; 🇪🇬 Alexandria, Egypt