Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 4
- 主要终点
- complete regression of respiratory failure
研究概览
简要总结
The aim of the study is to compare the efficiency on respiratory failure regression of high-flow nasal oxygen therapy versus standard oxygen in patients admitted to the ED for de novo acute respiratory failure.
详细描述
Prospective observational before-after study at the ED in two French centers.
Selection of patients with acute hypoxemic respiratory failure at the ED.
Application of oxygen strategy according to the period:
- before period: standard oxygen delivered through nasal cannula, face mask or non-rebreathing reservoir mask, with a flow rate adjusted to maintain a pulse oxymetry of at least 92%.
- after period: high-flow oxygen therapy continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min and a FiO2 adjusted to maintain a pulse oxymetry at least 92%.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •de novo acute respiratory failure cowith the following criteria: a respiratory rate > 25 b/min, or signs of increased work of breathing.
- •Main exclusion Criteria:
- •cardiogenic pulmonary edema,
- •acute exacerbation of chronic lung disease, respiratory acidosis (pH < 7.35 and PaCO2 > 50 mm Hg),
- •hemodynamic instability
- •Glasgow Coma Scale score of 12 points or less,
- •an urgent need for endotracheal intubation,
排除标准
- 未提供
研究组 & 干预措施
standard oxygen group
Patients are treated with standard oxygen delivered through nasal cannula, face mask or non-rebreathing reservoir
干预措施: Standard oxygen (Device)
High-flow oxygen group
Patients are treated with high-flow nasal cannula oxygen continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min
干预措施: High-flow oxygen (Device)
结局指标
主要结局
complete regression of respiratory failure
时间窗: one hour after initiation of oxygen strategies
respiratory rate less than 25 breaths per minute and regression of signs of increased work of breathing
次要结局
未报告次要终点