Oral microbiome and transcriptome as predictors of new cardiovascular events in patients with CHD and need for cardiac surgery

Recruiting

• Conditions: I25.1; K05.3; Atherosclerotic heart disease; Chronic periodontitis

• Registration Number: DRKS00015776
• Lead Sponsor: Martin-Luther-universität Halle-WittenbergUniversitätspoliklinik für Zhanerhaltungskunde und Parodontologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

unrelated Caucasians, > 50% stenosis of a major coronary artery; at least 4 own teeth, need for ACB surgery

Exclusion Criteria

lack of consent to participate in the study, diseases or dysfunctions that exclude participation in a clinical trial, participation in a clinical trial 30 days prior to initiation of this study, systematic periodontitis or antibiotic treatment 6 or 3 months prior to enrollment, pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of new cardiovascular events (combined endpoint: myocardial infarction, revascularization, stroke, transient ischemic attack, cardiac death, and death from stroke) one year after ACB surgery.

Secondary Outcome Measures

Name	Time	Method
Outcome 30 days after ACB surgery MACCE (major adverse cardiac and cerebrovascular events) criteria and 30-day lethality (combined endpoint).<br><br>Incidence of new cardiovascular events (combined endpoint: myocardial infarction, re-revascularization, stroke, transient ischemic attack, cardiac death, and death from stroke) three years after ACB surgery.