Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging

• Conditions: Coronary Artery Disease; Cardiac Perfusion
• Interventions: Procedure: SPECT Imaging; Procedure: Stress Adenosine CMR

• Registration Number: NCT00864591
• Lead Sponsor: Sheba Medical Center

Brief Summary

This study is designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) when compared with SPECT.

The investigators hypothesized that adenosine CMR could detect ischemia and is not inferior to SPECT imaging. In addition stress adenosine cardiac MRI offers a "one stop shop" enabling evaluation of cardiac function, rest and stress perfusion and viability.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-03
• Study First Submitted: 2009-03-04
• Study First Submitted QC: 2009-03-17
• Last Update Submitted: 2009-03-17
• Study First Posted: 2009-03-18
• Last Update Posted: 2009-03-18
• Study Start: 2009-04
• Primary Completion: 2010-04
• Study Completion: 2010-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Suspected ischemia referred to SPECT stress imaging

Exclusion Criteria

• Standard contraindications to MRI including (pacemaker/defibrillator, metallic clips on brain aneurysms, metal fragment in the eye, etc...)
• Congestive heart failure.
• Hemodynamic instability.
• History of asthma or bronchospastic disease.
• Arrhythmia
• Creatinine >1.4
• Non compliant patient, not able to lie supine in the MRI scanner for 1 hour.
• Pregnant patients
• Patients for whom the repeat stress might pose a significant risk.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
SPECT and stress CMR patients	SPECT Imaging	patients undergoing SPECT stress imaging, for the evaluation of myocardial ischemia. The study group will include patients with either normal undergoing SPECT stress imaging or with mild to severe ischemia, to include the entire spectrum of coronary artery disease. Patients will be pre selected and evaluated by a non-dependent cardiologist in order to verify that patients in whom the repeat stress might pose a serious risk will be excluded from the study.
SPECT and stress CMR patients	Stress Adenosine CMR	patients undergoing SPECT stress imaging, for the evaluation of myocardial ischemia. The study group will include patients with either normal undergoing SPECT stress imaging or with mild to severe ischemia, to include the entire spectrum of coronary artery disease. Patients will be pre selected and evaluated by a non-dependent cardiologist in order to verify that patients in whom the repeat stress might pose a serious risk will be excluded from the study.

Primary Outcome Measures

Name	Time	Method
Stress adenosine cardiac MRIis not inferior to SPECT imaging in diagnosing myocardial ischemia	1 year

Trial Locations

Locations (1)

Chaim Sheba Medical Center; 🇮🇱 Tel hashomer, Israel