Glucotoxity and Endothelial Functio

Withdrawn

• Conditions: diabetes mellitus; 10018424; 10003216

• Registration Number: NL-OMON31935
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Male or female type 2 diabetic patients; Documented GlycoHb > 8.5% for at least 6 weeks; Age 30-60 years; BMI 25-35 kg/m2; LDL-cholesterol concentration < 3.0 mmol/l; Blood pressure < 140/90 mmHg

Exclusion Criteria

(Clinical or laboratory) evidence of atherosclerosis or cardiovascular disease; Other systemic disorder with likelihood of (micro)vascular involvement; diabetic nephropathy (albuminuria > 300 mg per day); Kidney disease other than diabetes (serum creatinine > 120 µmol/l); Alcohol abuse; Unwillingness to give written informed consent; Condition that precludes follow-up; Oral anticoagulant therapy or bleeding diathesis

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess the relationship between glycemic control and endothelial function on<br /><br>the microvascular level in diabetes mellitus type 2 (NO, ET-1, Ang II). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To assess underlying mechanisms involved in microvascular endothelial<br /><br>dysfunction and possibly its improvement</p><br>