Analgesic and Anti-inflamatory Effect of Vit. B

Not Applicable

Not yet recruiting

• Conditions: Postoperative Pain, Acute
• Interventions: Drug: Vitamin B Complex; Drug: Placebo; Drug: vitamin C

• Registration Number: NCT06857734
• Lead Sponsor: Benha University

Brief Summary

Vitamin C, also known as ascorbic acid, is a potent reducing agent and antioxidant that plays a crucial role in various metabolic processes.Vitamin B complex, a group of eight essential B vitamins, plays a crucial role in cellular metabolism, energy production, and maintaining nervous system health. There are few available studies on the effects of vitamin B injection on plasma inflammatory markers and its adjuvant analgesic effect along with the routine multimodal analgesia. Considering limited research and existing controversies in this field, the aim of present study is to evaluate the effects of preoperative and intraoperative vitamin B12 administration compared to vitamin C when used as a component of the multimodal analgesic technique in patients undergoing laparoscopic cholecystectomy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-27
• Study First Submitted QC: 2025-02-27
• Last Update Submitted: 2025-02-27
• Study Start: 2025-03-01
• Study First Posted: 2025-03-04
• Last Update Posted: 2025-03-04
• Primary Completion: 2026-05-01
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Adult patients (age 18-60 years)
• American Society of Anesthesiologists (ASA) classification I-II
• Patients undergoing laparoscopic cholecystectomy under general anaesthesia

Exclusion Criteria

• Hypersensitivity to vitamin B complex or vitamin C
• History of chronic pain or use of opioids within the last month
• Patient with inflammatory conditions
• Severe renal or hepatic impairment
• Patient with intellectual disabilities.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group B	Vitamin B Complex	-
Group N	Placebo	-
Group C	vitamin C	-

Primary Outcome Measures

Name	Time	Method
The total dose of analgesics required postoperatively	within the first 24 hours and the time to first request

Trial Locations

Locations (1)

Benha university; 🇪🇬 Benha, Egypt