Effect of β-alanine Supplementation on Muscle Carnosine

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: beta-alanine; Dietary Supplement: placebo

• Registration Number: NCT00813553
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Detailed Description

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Study Timeline

• Study Start: 2008-12
• Study First Submitted: 2008-12-22
• Study First Submitted QC: 2008-12-22
• Study First Posted: 2008-12-23
• Primary Completion: 2009-10
• Study Completion: 2009-10
• Status Verified: 2012-04
• Last Update Submitted: 2012-04-24
• Last Update Posted: 2012-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Stable health as evaluated by medical evaluation
• Body mass index higher than 18 kg/m2
• Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion Criteria

• intolerance to β-alanine,
• allergy to soy, fish and crustacean
• participation in another intervention study
• consumer of dietary supplement susceptible to contain beta-alanine
• determined to have very high baseline muscle carnosine concentration

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
beta-alanine 2	beta-alanine	-
beta-alanine 0	placebo	-
beta-alanine 1	beta-alanine	-

Primary Outcome Measures

Name	Time	Method
muscle carnosine concentration	0 to 8 weeks

Trial Locations

Locations (1)

University and Inselspital; 🇨🇭 Bern, Switzerland