Neighborhoods, Networks, Depression, and HIV Risk

Phase 2

Completed

• Conditions: Drug Use; HIV; Depression
• Interventions: Behavioral: Workshop control; Behavioral: Workshop

• Registration Number: NCT01380613
• Lead Sponsor: Johns Hopkins Bloomberg School of Public Health

Brief Summary

The goal of this study is to examine how social networks, neighborhood, and depression are related to HIV risk. The intervention is designed to train individuals to cope with feelings of depression or stress as a way to reduce their risk for HIV.

Detailed Description

This study included implementation and evaluation of a small group, randomized controlled, phase II intervention to reduce depressive symptoms and HIV risk behaviors among inner city drug users. The intervention included elements of cognitive behavioral therapy (CBT) for depression among impoverished individuals, emphasizing depressive cognitions and behaviors theorized to be associated with depression and with HIV risk behaviors among mildly to moderately depressed drug users. In addition, the study examined active drug users' social and environmental pathways to depression and subsequent HIV risk behaviors. Specifically, we will hypothesized mediating/moderating effects of neighborhood characteristics, social network factors, and individual level factors on depressive symptoms and HIV risk behaviors.

Study Timeline

• Study Start: 2007-09
• Study First Submitted: 2011-03-07
• Study First Submitted QC: 2011-06-22
• Study First Posted: 2011-06-27
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-04
• Last Update Posted: 2013-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 965

Inclusion Criteria

1. 18-55 years old
2. HIV Risk Behavior:

3a. Injected drugs more than 3 times in the past week OR

3b. Snorted/sniffed heroin or cocaine or smoked crack in the past 6 months AND had 1 of the following sex risks in the past 6 months: i) 2 or more sex partners ii) Had a sex partner who injected drugs iii)Had a sex partner who smoked crack iv) Had a sex partner who was HIV+

4. Willingness to attend group sessions

Exclusion Criteria

1. Enrolled in another HIV behavioral intervention or depression study in past the 3 years
2. Enrolled in another Lighthouse study in past the 5 years
3. Enrolled in the formative research (Phase 1) or pilot (Phase 2) of the current project.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Workshop Control	Workshop control	Participants receive HIV/STDs risk reduction information.
Intervention Workshop	Workshop	Participants learn skills to cope with depressive symptoms and stress as well as safer sex and injection skills.

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Depressive Symptoms Measured by the CESD Scale at 12 months	12 months
Change from Baseline in Depressive Symptoms Measured by the CESD Scale at 6 months	6 months

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in Sex Risk Behavior Based on Number of Sex Partners and Condom Use at 12 months	12 months
Change from Baseline in Sex Risk Behavior Based on Number of Sex Partners and Condom Use at 6 months	6 months
Change from Baseline in Injection Risk Behavior Based on Sharing Needles, Cookers, and Cotton For Injection and Drug Splitting at 6 months	6 months
Change from Baseline in Injection Risk Behavior Based on Sharing Needles, Cookers, and Cotton For Injection and Drug Splitting at 12 months	12 months

Trial Locations

Locations (1)

Lighthouse Studies @ Peer Points- JHSPH; 🇺🇸 Baltimore, Maryland, United States