This is a study to compare the effects of three drugs which are intravenous Dexmedetomidine, Magnesium Sulphate and Esmolol in reducing the stress response during laryngoscopy and endotracheal intubation during general Anaesthesia

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2020/10/028693
• Lead Sponsor: MAULANA AZAD MEDICAL COLLEGE

Brief Summary

Securingthe airway is an essential component of anaesthesia care for patientsundergoing surgery under general anesthesia. Maneuvers such as laryngoscopy andendotracheal intubation are noxious stimuli associated with certaincardiovascular changes such as tachycardia, rise in blood pressure and varioustypes of cardiac arrhythmias. These hemodynamic changes are due to sympathoadrenal discharge causedby epipharyngeal and parapharyngeal stimulations. This can lead to various adverse events likemyocardial ischemia, pulmonary edema, acute heart failure and cerebrovascularaccidents in susceptible individuals. Various drugs like lignocaine, opioid analgesics, benzodiazepenes,beta blockers, alpha adrenergic blockers, calcium channel blockers andvasodilators have been tried with variable success to attenuate this stressresponse and provide haemodynamic stability perioperatively.

Dexmedetomidineis a highly selective α2 adrenergic agonist which provides anxiolysis,sedation, cardiovascular stability, analgesia, anterograde amnesia anddecreased exocrine secretions and thereby prevents hypertension andtachycardia.

Magnesiumsulphate is a calcium antagonist and can modify many calcium-mediatedresponses. It’s a cerebral depressant which acts by blocking theN-methyl-D-aspartate(NMDA) receptors and also decreases the sympathetic outflow.

Esmolol isan ultra-short acting cardioselective β-blocker with rapid onset which makes itan attractive option for attenuating the pressor and metabolic response tolaryngoscopy and intubation. So, we aim to compare Dexmedetomidine, Magnesium Sulphate and Esmolol in the attenuation of pressor stress response to laryngoscopy and endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-11
• Last Update Posted: 2020-10-16

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• 1.PATIENTS UNDERGOING ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA.
• AMERICAN SOCIETY OF ANAESTHESIOLOGISTS PHYSICAL STATUS I AND II PATIENTS.

Exclusion Criteria

• PATIENTS WITH KNOWN SENSITIVITY TO ANY STUDY DRUG.
• PREGNANT FEMALES.
• PATIENTS WITH CHRONIC HYPERTENSION AND DIABETES MELLITUS.
• PATIENTS WITH HISTORY OF CARDIAC OR RESPIRATORY ILLNESS.
• PATIENTS WITH ANTICIPATED DIFFICULT AIRWAY.
• PATIENTS WITH IMPAIRED KIDNEY OR LIVER FUNCTION.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE, MAGNESIUM SULPHATE AND ESMOLOL FOR ATTENUATION OF PRESSOR RESPONSE(HEART RATE AND BLOOD PRESSURE) TO DIRECT LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.	AT THE TIME OF ARRIVAL IN THE OPERATING ROOM, AND AT 1 MINUTE, 3 MINUTE, 5 MINUTE AND 10 MINUTE AFTER INTUBATION.

Secondary Outcome Measures

Name	Time	Method
COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE, MAGNESIUM SULPHATE AND ESMOLOL FOR ATTENUATION OF METABOLIC STRESS RESPONSE(SERUM CORTISOL AND BLOOD GLUCOSE) TO DIRECT LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.	AT THE TIME OF ARRIVAL IN THE OPERATING ROOM AND 10 MINUTES AFTER INTUBATION.

Trial Locations

Locations (1)

MAULANA AZAD MEDICAL COLLEGE AND ASSOCIATED HOSPITALS; 🇮🇳 Delhi, DELHI, India

MAULANA AZAD MEDICAL COLLEGE AND ASSOCIATED HOSPITALS

🇮🇳Delhi, DELHI, India

KAJOL AGGARWAL

Principal investigator

9899374284

kajol.aggarwal11@gmail.com